Enantiomeric resolution of new triazole compounds by high-performance liquid chromatography

Cellulose tris(3,5‐dimethylphenylcarbamate) (CDMPC) was synthesized and coated on aminopropylsilica to prepare a chiral stationary phase (CSP). HPLC methods were developed for the direct enantioseparation of 12 chiral triazole compounds on the CSP. The separations were made using normal phase method...

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Bibliographic Details
Published in:Journal of separation science 2007-02, Vol.30 (3), p.344-351
Main Authors: Lv, Chunguang, Jia, Guifang, Zhu, Wentao, Qiu, Jing, Wang, Xinquan, Zhou, Zhiqiang
Format: Article
Language:English
Subjects:
Analytical chemistry
Chemistry
Chiral triazole
Chromatographic methods and physical methods associated with chromatography
Enantiomer separation
Exact sciences and technology
HPLC
Other chromatographic methods
Polysaccharide carbamate phase
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Summary:Cellulose tris(3,5‐dimethylphenylcarbamate) (CDMPC) was synthesized and coated on aminopropylsilica to prepare a chiral stationary phase (CSP). HPLC methods were developed for the direct enantioseparation of 12 chiral triazole compounds on the CSP. The separations were made using normal phase methodology with a mobile phase consisting of n‐hexane‐alcohol (ethanol, 1‐propanol, 1‐butanol, 2‐propanol, and t‐butanol) in various portions. The column temperatures were studied for the optimization of the resolutions. The effects of structural features of the solutes on the discrimination between the enantiomers were examined. Baseline separation was easily obtained in many cases.
ISSN:1615-9306
1615-9314
DOI:10.1002/jssc.200600282