Allelic polymorphism in the Plasmodium vivax dihydrofolate reductase gene among Indian field isolates

In total, 129 Plasmodium vivax isolates from different geographical areas in India were analysed for point mutations in the P. vivax dihydrofolate reductase gene that were associated with pyrimethamine resistance. A gradual increase in the frequency of mutant genotypes was observed from north to sou...

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Bibliographic Details
Published in:Clinical microbiology and infection 2007-03, Vol.13 (3), p.331-334
Main Authors: Prajapati, S.K., Joshi, H., Valecha, N., Reetha, A.M., Eapen, A., Kumar, A., Das, M.K., Yadav, R.S., Rizvi, M.A., Dash, A.P.
Format: Article
Language:English
Subjects:
Alleles
Allelic polymorphism
Animals
Biological and medical sciences
dihydrofolate reductase gene
genotypes
geographical distribution
Human protozoal diseases
Infectious diseases
Malaria
Medical sciences
Mutation
Parasitic diseases
Plasmodium vivax
Plasmodium vivax - enzymology
Plasmodium vivax - genetics
Polymorphism, Genetic
Protozoal diseases
Tetrahydrofolate Dehydrogenase - genetics
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Summary:In total, 129 Plasmodium vivax isolates from different geographical areas in India were analysed for point mutations in the P. vivax dihydrofolate reductase gene that were associated with pyrimethamine resistance. A gradual increase in the frequency of mutant genotypes was observed from north to south (p
ISSN:1198-743X
1469-0691
DOI:10.1111/j.1469-0691.2006.01639.x