Expression of LH receptor mRNA splice variants in bovine granulosa cells: changes with follicle size and regulation by FSH in vitro

In cattle, most evidence suggests that granulosa cells express LH receptors (LHR) after (or as) the follicle becomes dominant, however there is some suggestion that granulosa cells from smaller pre‐dominant follicles may express several LHR mRNA splice variants. The objective of this study was to me...

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Bibliographic Details
Published in:Molecular reproduction and development 2007-06, Vol.74 (6), p.680-686
Main Authors: Nogueira, M.F.G., Buratini, J., Price, C.A., Castilho, A.C.S., Pinto, M.G.L., Barros, C.M.
Format: Article
Language:English
Subjects:
Alternative Splicing
Animals
antral follicles
Biological and medical sciences
bovine
Cattle - genetics
Cell Size
Cells, Cultured
Dose-Response Relationship, Drug
Female
Follicle Stimulating Hormone - pharmacology
Fundamental and applied biological sciences. Psychology
gene expression
Granulosa Cells - drug effects
Granulosa Cells - metabolism
Hormone metabolism and regulation
luteinizing hormone receptor
Mammalian female genital system
Ovarian Follicle - cytology
Ovarian Follicle - drug effects
Ovarian Follicle - metabolism
Protein Isoforms - genetics
Protein Isoforms - metabolism
Receptors, LH - genetics
Receptors, LH - metabolism
RNA, Messenger
RT-PCR
Vertebrates: reproduction
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Summary:In cattle, most evidence suggests that granulosa cells express LH receptors (LHR) after (or as) the follicle becomes dominant, however there is some suggestion that granulosa cells from smaller pre‐dominant follicles may express several LHR mRNA splice variants. The objective of this study was to measure LHR expression in bovine follicles of defined size and steroidogenic ability, and in granulosa cells from small follicles (
ISSN:1040-452X
1098-2795
DOI:10.1002/mrd.20656