Butterbur root extract and music therapy in the prevention of childhood migraine: An explorative study

Abstract Background Migraine is very common in school-aged children, but despite a number of pharmacological and non-pharmacological options for prophylaxis, randomized controlled evidence in children is small. Evidence-based prophylactic drugs may have considerable side effects. Objective This stud...

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Bibliographic Details
Published in:European journal of pain 2008-04, Vol.12 (3), p.301-313
Main Authors: Oelkers-Ax, Rieke, Leins, Anne, Parzer, Peter, Hillecke, Thomas, Bolay, Hans V, Fischer, Jochen, Bender, Stephan, Hermanns, Uta, Resch, Franz
Format: Article
Language:English
Subjects:
Anesthesia & Perioperative Care
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Butterbur root extract
Child
Children
Combined Modality Therapy
Double-Blind Method
Efficacy
Family
Female
Follow-Up Studies
Humans
Imagery (Psychotherapy)
Male
Mental Disorders - epidemiology
Migraine Disorders - prevention & control
Migraine Disorders - psychology
Migraine prophylaxis
Music Therapy
Pain Medicine
Patient Compliance
Patient Education as Topic
Petasites
Phytotherapy
Plant Extracts - administration & dosage
Plant Extracts - therapeutic use
Plant Roots - chemistry
Prospective Studies
Relaxation Therapy
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Summary:Abstract Background Migraine is very common in school-aged children, but despite a number of pharmacological and non-pharmacological options for prophylaxis, randomized controlled evidence in children is small. Evidence-based prophylactic drugs may have considerable side effects. Objective This study was to assess efficacy of a butterbur root extract (Petadolex® ) and music therapy in primary school children with migraine. Design Prospective, randomized, partly double-blind, placebo-controlled, parallel-group trial. Methods Following a 8-week baseline patients were randomized and received either butterbur root extract ( n = 19), music therapy ( n = 20) or placebo ( n = 19) over 12 weeks. All participants received additionally headache education (“treatment as usual”) from the baseline onwards. Reduction of headache frequency after treatment (8-week post-treatment) as well as 6 months later (8-week follow-up) was the efficacy variable. Results Data analysis of subjects completing the respective study phase showed that during post-treatment, only music therapy was superior to placebo ( p = 0.005), whereas in the follow-up period both music therapy and butterbur root extract were superior to placebo ( p = 0.018 and p = 0.044, respectively). All groups showed a substantial reduction of attack frequency already during baseline. Conclusion Butterbur root extract and music therapy might be superior to placebo and may represent promising treatment approaches in the prophylaxis of paediatric migraine.
ISSN:1090-3801
1532-2149
DOI:10.1016/j.ejpain.2007.06.003