HER-2/neu overexpression is an independent prognostic factor in colorectal cancer

The HER-2/neu protein is intimately involved with normal cell proliferation and tissue growth, as it is extensively homologous and is related to the epidermal growth factor receptor. This phenomenon has been most intensively studied in the context of breast carcinoma, in which its amplification and...

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Published in:International journal of colorectal disease 2007-05, Vol.22 (5), p.491-497, Article 491
Main Authors: DONG IL PARK, MUN SU KANG, SEUNG HO RYU, SEPULVEDA, Antonia R, SUK JOONG OH, HONG JOO KIM, YONG KYUN CHO, CHONG IL SOHN, WOO KYU JEON, BYUNG IK KIM, WON KON HAN, KIM, Hungdai
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Breast cancer
Breast carcinoma
Cell proliferation
Chemotherapy
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - genetics
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
Colorectal Neoplasms - surgery
Endocrine therapy
Epidermal growth factor
ErbB-2 protein
Female
Fluorescence in situ hybridization
Gastroenterology. Liver. Pancreas. Abdomen
Gene Amplification
Gene Expression Profiling
Gynecology. Andrology. Obstetrics
HER protein
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Korea - epidemiology
Male
Mammary gland diseases
Medical sciences
Middle Aged
Monoclonal antibodies
Multivariate Analysis
Neoplasm Recurrence, Local - genetics
Patients
Prognosis
Proportional Hazards Models
Receptor, ErbB-2 - genetics
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Survival Rate
Tumors
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Summary:The HER-2/neu protein is intimately involved with normal cell proliferation and tissue growth, as it is extensively homologous and is related to the epidermal growth factor receptor. This phenomenon has been most intensively studied in the context of breast carcinoma, in which its amplification and overexpression correlate with the overall course of disease and poor prognoses, and also constitute a predictive factor of poor response to chemotherapy and endocrine therapy. In this study, we investigated the relationships between the expression of HER-2/neu and the clinicopathological characteristics of colorectal cancer, including survival. This study was performed with a view toward the future introduction of Herceptin therapy for colorectal cancer patients. HER-2/neu overexpression and gene amplification were examined via semiquantitative standardized immunohistochemical staining and fluorescence in situ hybridization (FISH) in 137 colorectal cancer patients who underwent curative surgery at the Kangbuk Samsung Hospital. Sixty-five (47.4%) out of 137 patients were determined by immunohistochemistry to have overexpressed HER-2/neu protein. HER-2/neu gene amplification was detected in two patients by FISH. Tumors with HER-2/neu overexpression showed higher postoperative recurrence rate (39.3% vs 14.6%, p=0.013). Tumors with HER-2/neu overexpression were associated with poor 3-year (70.8% vs 83.7%) and 5-year survival rates (55.1% vs 78.3%, p
ISSN:0179-1958
1432-1262
DOI:10.1007/s00384-006-0192-8