Gated SPECT imaging to detect changes in myocardial blood flow during progressive coronary occlusion

Background : The ability to track dynamic changes in myocardial blood flow (MBF) and wall motion with serial gated perfusion imaging may be a limiting factor in assessing new therapies. The purpose of this study was to determine whether gated Tc-99 m sestamibi (MIBI) SPECT imaging can track small ch...

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Bibliographic Details
Published in:The International Journal of Cardiovascular Imaging 2008-03, Vol.24 (3), p.269-276
Main Authors: Christian, Timothy F., Peters, Kevin, Keck, Bradly, Allen, Jill, Owens, Thomas, Borah, Babul
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Cardiac Imaging
Cardiology
Coronary Circulation
Coronary Occlusion - diagnostic imaging
Disease Models, Animal
Disease Progression
Imaging
Medicine
Medicine & Public Health
Myocardial Infarction - diagnostic imaging
Original Paper
Radiology
Radiopharmaceuticals
Swine
Technetium Tc 99m Sestamibi
Tomography, Emission-Computed, Single-Photon - methods
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Summary:Background : The ability to track dynamic changes in myocardial blood flow (MBF) and wall motion with serial gated perfusion imaging may be a limiting factor in assessing new therapies. The purpose of this study was to determine whether gated Tc-99 m sestamibi (MIBI) SPECT imaging can track small changes in MBF in a model of progressive ischemia. Methods : Eight pigs (20 kg) underwent lateral thoracotomy for placement of an ameroid constrictor on the left circumflex coronary artery (LCX) and indwelling femoral and left atrial catheters for serial microsphere determinations of absolute MBF. Animals underwent concurrent left atrial microsphere and Tc-99 m sestamibi (0.3 mCi/Kg IV) injections at weekly intervals over 6 weeks per animal. Gated SPECT imaging was acquired for each injection using high resolution collimation and standard processing. The animals were sacrificed on day 42. Mean signal intensity (SI) from regions of interest (ROI) corresponding to control and ischemic MBF by microspheres was measured for three SPECT short-axis images. Mean contrast ratio (MCR) was calculated from the ratio of ischemic to control SI per slice. Regional wall motion (RWM) from gated images was scored 1–5 using a 16 segment model and a score index (RWMI) was calculated. Results : MBF decreased progressively (27% below resting values [ P  
ISSN:1569-5794
1573-0743
1875-8312
DOI:10.1007/s10554-007-9255-3