Plasma Visfatin Concentration as a Surrogate Marker for Visceral Fat Accumulation in Obese Children

Objective: This study was designed to elucidate whether the plasma visfatin level reflects visceral or subcutaneous fat accumulation and metabolic derangement in obese children. Methods and Procedures: Fifty‐six obese Japanese children, including 37 boys and 19 girls were enrolled in the study. The...

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Bibliographic Details
Published in:Obesity (Silver Spring, Md.) Md.), 2008-02, Vol.16 (2), p.384-388
Main Authors: Araki, Shunsuke, Dobashi, Kazushige, Kubo, Kazuyasu, Kawagoe, Rinko, Yamamoto, Yukiyo, Kawada, Yasusada, Asayama, Kohtaro, Shirahata, Akira
Format: Article
Language:English
Subjects:
Adipocytes
Adiposity - ethnology
Adiposity - physiology
Adolescent
Age
Biomarkers - blood
Body Composition - physiology
Body fat
Case-Control Studies
Child
Children & youth
Environmental health
Enzymes
Epidemiology
Female
Homeostasis
Humans
Insulin resistance
Intra-Abdominal Fat - metabolism
Japan
Leptin - blood
Male
Metabolic syndrome
Nicotinamide Phosphoribosyltransferase - blood
Obesity
Obesity - blood
Obesity - ethnology
Plasma
Proteins
Subcutaneous Fat - metabolism
Tomography
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Summary:Objective: This study was designed to elucidate whether the plasma visfatin level reflects visceral or subcutaneous fat accumulation and metabolic derangement in obese children. Methods and Procedures: Fifty‐six obese Japanese children, including 37 boys and 19 girls were enrolled in the study. The age of the subjects ranged from 5 to 15 (10.2 ± 0.3; mean ± s.e.m.) years. The age‐matched control group for measuring visfatin consisted of 20 non‐obese children. Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) areas were measured by computed tomography. The plasma concentrations for visfatin and leptin were assayed by enzyme‐linked immunosorbent assay kits. Results: The plasma visfatin level was higher in the obese (14.7 ± 0.9 ng/ml) than in the control children (8.6 ± 0.6 ng/ml). In a univariate analysis, the visfatin correlated significantly with age, height, body weight, waist circumference, VAT and SAT area, triglyceride (TG), insulin, and the homeostasis model assessment for insulin resistance (HOMA‐R). After being adjusted for age and sex, only the VAT area retained significant partial correlation with visfatin, and in contrast the body weight, BMI–s.d., and SAT area with leptin. The plasma visfatin concentration was not correlated with leptin. The plasma visfatin levels in the control, non‐metabolic syndrome (MS) (n = 49), and MS groups (n = 7) were significantly different from each other. Discussion: These results suggest that plasma visfatin level is a specific marker for visceral fat accumulation in obese children. As a good surrogate marker, plasma visfatin level can predict the VAT area in obese children.
ISSN:1930-7381
1930-739X
DOI:10.1038/oby.2007.54