Methylprednisolone administration alters adenine nucleotide hydrolysis in rat blood serum

The effect of methylprednisolone on the hydrolysis of adenine nucleotides by rat blood serum enzymes was studied. Adult male Wistar rats were submitted to three different treatments with synthetic steroid methylprednisolone: one dose of 50 mg/kg, i.p. (acute); or oral doses of 6 mg/kg dissolved in d...

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Published in:European journal of pharmacology 2007-04, Vol.560 (2), p.212-215
Main Authors: Torres, Iraci Lucena S., Fürstenau, Cristina Ribas, Rossi, Gabriela, Dallegrave, Eliane, Dallegrave, Gustavo, Stenzel, Barbara, Dantas, Giovana, Battastini, Ana Maria O., Sarkis, João J.F., Ferreira, Maria Beatriz C.
Format: Article
Language:English
Subjects:
5′nucleotidase
Adenine Nucleotides - blood
ADPase
Aging - metabolism
Animals
ATPase
Biological and medical sciences
Hydrolysis
Male
Medical sciences
Methylprednisolone
Methylprednisolone - pharmacology
Pharmacology. Drug treatments
Rat blood serum
Rats
Rats, Wistar
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Summary:The effect of methylprednisolone on the hydrolysis of adenine nucleotides by rat blood serum enzymes was studied. Adult male Wistar rats were submitted to three different treatments with synthetic steroid methylprednisolone: one dose of 50 mg/kg, i.p. (acute); or oral doses of 6 mg/kg dissolved in drinking water for 15 (sub-chronic) or 30 (chronic) days. Decreased ADP hydrolysis was observed after acute and sub-chronic treatments. Furthermore, ATP, ADP and AMP hydrolysis decreased after chronic treatment. These alterations may constitute one of the mechanisms that mediate the development of some of the side effects associated with corticosteroid use.
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2006.12.021