Adipokines and cytokines in non‐alcoholic fatty liver disease

Summary Background  Several adipocytokines have been implicated in the pathogenesis non‐alcoholic fatty liver disease (NAFLD). Aim  To assess adipocytokines in NAFLD patients and controls. Methods  A total of 95 patients (26 non‐alcoholic steatohepatitis (NASH), 19 simple steatosis (SS), 38 obese co...

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Published in:Alimentary pharmacology & therapeutics 2008-03, Vol.27 (5), p.412-421
Main Authors: JARRAR, M. H., BARANOVA, A., COLLANTES, R., RANARD, B., STEPANOVA, M., BENNETT, C., FANG, Y., ELARINY, H., GOODMAN, Z., CHANDHOKE, V., YOUNOSSI, Z. M.
Format: Article
Language:English
Subjects:
Adipokines - blood
Adiponectin - blood
Adult
Aged
Biological and medical sciences
Biopsy
Blood Glucose - analysis
Case-Control Studies
Cohort Studies
Cytokines - blood
Digestive system
Fasting
Fatty Liver - blood
Fatty Liver - complications
Fatty Liver - etiology
Fatty Liver - surgery
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Immunoenzyme Techniques
Insulin - blood
Insulin Resistance
Interleukin-6 - blood
Interleukin-8 - blood
Linear Models
Liver - surgery
Liver Cirrhosis - blood
Liver Cirrhosis - pathology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Middle Aged
Multivariate Analysis
Nicotinamide Phosphoribosyltransferase - blood
Obesity - complications
Other diseases. Semiology
Pharmacology. Drug treatments
Resistin - blood
Tumor Necrosis Factor-alpha - blood
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Summary:Summary Background  Several adipocytokines have been implicated in the pathogenesis non‐alcoholic fatty liver disease (NAFLD). Aim  To assess adipocytokines in NAFLD patients and controls. Methods  A total of 95 patients (26 non‐alcoholic steatohepatitis (NASH), 19 simple steatosis (SS), 38 obese controls and 12 non‐obese controls) were included. Fasting serum insulin, glucose, visfatin, resistin, adiponectin, tumour necrosis factor‐α (TNF‐α), interleukin‐8 (IL‐8) and IL‐6 were determined. Univariate and multivariate analyses were used to compare groups and determine associations. Results  Serum TNF‐α and IL‐8 were higher in NAFLD patients when compared with both obese and non‐obese controls. Analysis involving all patients revealed a significant correlation between serum TNF‐α and IL‐8 (P 
ISSN:0269-2813
1365-2036
DOI:10.1111/j.1365-2036.2007.03586.x