Prevalence and Cluster of Cardiometabolic Biomarkers in Overweight and Obese Schoolchildren: Results from a Large Survey in Southwest Germany

Obesity is associated with substantial metabolic changes and subclinical inflammation. We explored associations between body mass index (BMI) and cardiometabolic biomarkers and their clustering in overweight and obese schoolchildren. In this population-based, cross-sectional study among 450 children...

Full description

Saved in:

Bibliographic Details
Published in:	Clinical chemistry (Baltimore, Md.) Md.), 2008-02, Vol.54 (2), p.317-325
Main Authors:	Nagel, Gabriele, Rapp, Kilian, Wabitsch, Martin, Buchele, Gisela, Kroke, Anja, Zollner, Iris, Weiland, Stephan K, Koenig, Wolfgang
Format:	Article
Language:	eng
Subjects:	1-Alkyl-2-acetylglycerophosphocholine Esterase - blood Adiponectin - blood Analytical, structural and metabolic biochemistry Apolipoprotein A-I - blood Apolipoproteins B - blood Atherosclerosis Biological and medical sciences Biological markers Body Mass Index C-reactive protein C-Reactive Protein - analysis Cardiovascular disease Child Children Children & youth Cross-Sectional Studies Elementary school students Fibrin Fibrinogen Fibrinogen - analysis Fundamental and applied biological sciences. Psychology Germany - epidemiology Health aspects Humans Inflammation Inflammation - metabolism Interleukin-6 - blood Investigative techniques, diagnostic techniques (general aspects) Leptin Leptin - blood Linear Models Logistic Models Medical sciences Metabolism Nutrition Obesity Obesity - epidemiology Obesity - metabolism Obesity in children Overweight - epidemiology Overweight - metabolism Peptide hormones Phospholipases Prevalence studies (Epidemiology) Surveys
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Obesity is associated with substantial metabolic changes and subclinical inflammation. We explored associations between body mass index (BMI) and cardiometabolic biomarkers and their clustering in overweight and obese schoolchildren. In this population-based, cross-sectional study among 450 children 10 years old, we measured adiponectin, leptin, inflammatory markers, apolipoprotein (apo) AI and B, and lipoprotein-associated phospholipase A(2) (Lp-PLA(2)). Except for adiponectin and apoAI (10th percentile) the 90th percentile was used as cutoff point. Body weight was categorized in age- and sex-specific BMI percentiles and overweight and obesity according to International Obesity Task Force definitions. In linear regression models, all cardiometabolic markers except apoB were statistically significantly associated with overweight. In logistic regression models, compared with the reference category (25th-75th percentile of BMI), overweight was associated with increased concentrations of leptin [odds ratio (OR) 59.80; 95% CI 16.68-214.39], C-reactive protein (6.30; 2.95-13.45), fibrinogen (2.82; 1.33-6.01), and low apoAI (2.62; 1.19-5.75). Overweight was positively associated with interleukin-6, Lp-PLA(2), and apoB concentrations and inversely with adiponectin concentrations. Most importantly, in obese children 35% showed one, 20% two, 10% three, and 15% four or more abnormal cardiometabolic biomarkers. The number of abnormal cardiometabolic markers increased in overweight (p(trend)
ISSN:	0009-9147 1530-8561