Polymorphisms of Two Indels at the PRNP Gene in Three Beef Cattle Herds

Bovine spongiform encephalopathy (BSE) is a transmissible fatal neurodegenerative disorder, presenting a characteristic spongiform degeneration of cattle brain due to the accumulation of a pathogenic and protease-resistant infectious protein (prion). Two deletion/insertion polymorphisms of the prion...

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Bibliographic Details
Published in:Biochemical genetics 2008-02, Vol.46 (1-2), p.1-7
Main Authors: Kerber, Alexandre R, Hepp, Diego, Passos, Daniel T, de Azevedo Weimer, Tania
Format: Article
Language:English
Subjects:
Animals
Base Sequence - genetics
Biochemistry
Biomedical and Life Sciences
Biomedicine
Brain - metabolism
Brain - pathology
Brazil
Breeding
cattle
Cattle - genetics
Cattle - metabolism
Disease Outbreaks - prevention & control
Encephalopathy, Bovine Spongiform - epidemiology
Encephalopathy, Bovine Spongiform - genetics
Encephalopathy, Bovine Spongiform - metabolism
Encephalopathy, Bovine Spongiform - pathology
Gene Frequency
Genetic Predisposition to Disease
Haplotypes
Human Genetics
Insertion/deletion polymorphism
Introns - genetics
Medical Microbiology
Note Banner
Polymorphism, Genetic
Prion disease
Prions - genetics
Prions - metabolism
Promoter Regions, Genetic - genetics
Sequence Deletion - genetics
Transmissible spongiform encephalopathy
Zoology
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Summary:Bovine spongiform encephalopathy (BSE) is a transmissible fatal neurodegenerative disorder, presenting a characteristic spongiform degeneration of cattle brain due to the accumulation of a pathogenic and protease-resistant infectious protein (prion). Two deletion/insertion polymorphisms of the prion protein gene (23 bp at the promoter region and 12 bp at intron 1) were analyzed in three beef cattle herds (Aberdeen Angus, Charolais, and Franqueiro) to verify allele frequencies for possible use in selection of resistant animals. High frequencies of susceptibility alleles (23 and 12 bp deletion) and haplotype (23 del/12 del) were observed in the Aberdeen Angus and Charolais herds, but Franqueiro presented one of the highest frequencies of resistant alleles so far described. These data indicate the need for selection in Aberdeen Angus and Charolais breeds to increase the frequency of resistant animals in order to reduce the probabilities of BSE outbreaks in these populations.
ISSN:0006-2928
1573-4927
DOI:10.1007/s10528-007-9113-y