The peroxisome proliferator-activated receptor gamma (PPAR-γ2) Pro12Ala polymorphism is associated with higher risk for Alzheimer's disease in octogenarians

Abstract Recent observations support the hypothesis that inflammatory processes at the brain level may contribute to the pathogenesis of Alzheimer's disease (AD). Peroxisome proliferator-activated receptor gamma (PPAR-γ) is involved in such processes, so we thought it interesting to study the P...

Full description

Saved in:
Bibliographic Details
Published in:Brain research 2007-03, Vol.1139, p.1-5
Main Authors: Scacchi, Renato, Pinto, Alessandro, Gambina, Giuseppe, Rosano, Aldo, Corbo, Rosa Maria
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Age of Onset
Aged
Aged, 80 and over
Alzheimer Disease - genetics
Alzheimer's disease
Apolipoprotein E4 - genetics
Biological and medical sciences
Case-Control Studies
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
DNA polymorphism
Female
Gene Frequency
Humans
Logistic Models
Male
Medical sciences
Neurology
Odds Ratio
Organic mental disorders. Neuropsychology
Peroxisome proliferator-activated receptor gamma (PPAR-γ2)
Polymorphism, Single Nucleotide
PPAR gamma - genetics
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Reference Values
Risk Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Recent observations support the hypothesis that inflammatory processes at the brain level may contribute to the pathogenesis of Alzheimer's disease (AD). Peroxisome proliferator-activated receptor gamma (PPAR-γ) is involved in such processes, so we thought it interesting to study the Pro12Ala polymorphism in exon 2 of the gene in a sample of late-onset AD patients. We found that Ala genotypes were significantly overrepresented among octogenarian patients compared to controls ( p = 0.034). Using logistic regression we observed that carrying the Ala allele significantly increased by nearly two-fold the risk of developing AD in subjects 80 years or older (OR = 1.98; 95% CI 1.03–3.80, p = 0.04). Though this difference was borderline significant after correction for multiple comparisons, our results suggest a possible involvement of the PPAR-γ gene in susceptibility to late-onset AD in octogenarians.
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2006.12.078