The effect of early virological response in health-related quality of life in HCV-infected patients

Twenty‐nine HCV‐infected patients were treated with pegylated interferon alpha. Diagnosis was based on serum HCV RNA‐PCR positive results and liver biopsy. All patients had elevated serum levels of alanine aminotransferase at the time of the study, but liver disease was compensated. Patients were ev...

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Bibliographic Details
Published in:Journal of medical virology 2008-03, Vol.80 (3), p.419-423
Main Authors: Quarantini, Lucas C., Miranda-Scippa, Ângela, Batista-Neves, Susana, Galvão-de-Almeida, Amanda, Lacerda, Acioly L., Moriyama, Taís S., Sampaio, Aline S., Melcop, Ana C., Schinoni, Maria I., de Oliveira, Irismar R., Paraná, Raymundo, Bressan, Rodrigo A.
Format: Article
Language:English
Subjects:
Antiviral Agents - therapeutic use
Biological and medical sciences
depression
Female
Fundamental and applied biological sciences. Psychology
Health Surveys
Hepacivirus - isolation & purification
hepatitis C
Hepatitis C virus
Hepatitis C, Chronic - drug therapy
Hepatitis C, Chronic - psychology
Hepatitis C, Chronic - virology
Human viral diseases
Humans
Infectious diseases
interferon alpha
Interferon-alpha - administration & dosage
Interferon-alpha - therapeutic use
Male
Medical sciences
Microbiology
Middle Aged
Miscellaneous
Polyethylene Glycols - administration & dosage
Polyethylene Glycols - therapeutic use
Quality of Life
Recombinant Proteins
RNA, Viral - blood
Viral diseases
Virology
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Summary:Twenty‐nine HCV‐infected patients were treated with pegylated interferon alpha. Diagnosis was based on serum HCV RNA‐PCR positive results and liver biopsy. All patients had elevated serum levels of alanine aminotransferase at the time of the study, but liver disease was compensated. Patients were evaluated at baseline treatment and after 4 and 12 weeks of antiviral treatment with the Medical Outcomes Study 36‐item Short‐Form Health Survey. The Mini‐International Neuropsychiatric Interview was used to exclude previous or current psychiatric diagnoses. Both patients and psychiatrists were blind to the HCV RNA status, and serum HCV RNA test results only became available after the visit at week 12. After antiviral treatment, 16 patients (55.2%) were classified as nonresponders and 13 (44.8%) were classified as responders. When compared to nonresponders, responders had a greater improvement in the HRQOL scores for the mental health domain (P 
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.21094