Identification of differentially expressed genes in the developing antler of red deer Cervus elaphus

Understanding the molecular mechanisms underlying bone development is a fundamental and fascinating problem in developmental biology, with significant medical implications. Here, we have identified the expression patterns for 36 genes that were characteristic or dominant in the consecutive cell diff...

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Bibliographic Details
Published in:Molecular genetics and genomics : MGG 2007-03, Vol.277 (3), p.237-248
Main Authors: Molnár, Andrea, Gyurján, István, Korpos, Éva, Borsy, Adrienn, Stéger, Viktor, Buzás, Zsuzsanna, Kiss, Ibolya, Zomborszky, Zoltán, Papp, Péter, Deák, Ferenc, Orosz, László
Format: Article
Language:English
Subjects:
AFLP-based differential display
Animals
Annexins - metabolism
Antler development
Antlers - growth & development
Antlers - metabolism
Base Sequence
Cervus elaphus
Chondrogenesis - genetics
Cloning, Molecular
Deer - genetics
Deer - growth & development
Deer - metabolism
DNA, Complementary - genetics
Gene expression
Gene Expression Profiling
Gene Expression Regulation, Developmental
Humans
Immunohistochemistry
In Situ Hybridization
Male
Mice
Proteins
RNA, Messenger - genetics
RNA, Messenger - metabolism
Robust bone development
Sequence Homology, Nucleic Acid
Species Specificity
Tumor associated genes
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Summary:Understanding the molecular mechanisms underlying bone development is a fundamental and fascinating problem in developmental biology, with significant medical implications. Here, we have identified the expression patterns for 36 genes that were characteristic or dominant in the consecutive cell differentiation zones (mesenchyme, precartilage, cartilage) of the tip section of the developing velvet antler of red deer Cervus elaphus. Two major functional groups of these genes clearly outlined: six genes linked to high metabolic demand and other five to tumor biology. Our study demonstrates the advantages of the antler as a source of mesenchymal markers, for distinguishing precartilage and cartilage by different gene expression patterns and for identifying genes involved in the robust bone development, a striking feature of the growing antler. Putative roles for “antler” genes that encode α-tropomyosine (tpm1), transgelin (tagln), annexin 2 (anxa2), phosphatidylethanolamine-binding protein (pebp) and apolipoprotein D (apoD) in intense but still controlled tissue proliferation are discussed.
ISSN:1617-4615
1617-4623
DOI:10.1007/s00438-006-0193-x