Plasma Natriuretic Peptide Concentrations as a Predictor for Successful Catheter Ablation in Patients With Drug-Refractory Atrial Fibrillation

Background The concentrations of atrial and brain natriuretic peptides (ANP and BNP) are elevated in patients with atrial fibrillation (AF), but the usefulness of their measurement before and after AF ablation has not been reported. Methods and Results The concentrations of the natriuretic peptides...

Full description

Saved in:
Bibliographic Details
Published in:Circulation Journal 2007, Vol.71(3), pp.313-320
Main Authors: Kurosaki, Kenji, Tada, Hiroshi, Hashimoto, Tohru, Ito, Sachiko, Miyaji, Kohei, Naito, Shigeto, Oshima, Shigeru, Taniguchi, Koichi
Format: Article
Language:English
Subjects:
Aged
Atrial fibrillation
Atrial Fibrillation - diagnosis
Atrial Fibrillation - therapy
Atrial Natriuretic Factor - blood
Atrial natriuretic peptide
Brain natriuretic peptide
Catheter ablation
Catheter Ablation - methods
Drug Resistance
Electrocardiography, Ambulatory
Female
Humans
Male
Middle Aged
Natriuretic Peptide, Brain - blood
Predictive Value of Tests
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background The concentrations of atrial and brain natriuretic peptides (ANP and BNP) are elevated in patients with atrial fibrillation (AF), but the usefulness of their measurement before and after AF ablation has not been reported. Methods and Results The concentrations of the natriuretic peptides were evaluated in 54 patients undergoing catheter ablation for drug-resistant paroxysmal and persistent AF without heart failure. Based on the outcome, the patients were divided into 2 groups: successful (n=42) or failure (n=12). All patients were asked to keep a log of the duration and frequency of their symptoms and underwent 24-h ECG monitoring at least once after the ablation. The plasma BNP and ANP concentrations, most of which were well below the heart failure range, exceeded the normal range in 69% and 26% of the patients, respectively. The BNP concentration decreased after ablation in the success group (49±43 to 27±28 pg/ml; p
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.71.313