Age-related increases in circulating inflammatory markers in men are independent of BMI, blood pressure and blood lipid concentrations

Abstract Objective To examine whether age-related increase in concentrations of circulating inflammatory mediators is due to concurrent increases in cardiovascular risk factors or is independent of these. Methods and results Cytokines (IL-6, IL-18), chemokines (6Ckine, MCP-1, IP-10), soluble adhesio...

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Published in:Atherosclerosis 2008-01, Vol.196 (1), p.298-305
Main Authors: Miles, Elizabeth A, Rees, Dinka, Banerjee, Tapati, Cazzola, Roberta, Lewis, Sian, Wood, Richard, Oates, Rachael, Tallant, Anna, Cestaro, Benvenuto, Yaqoob, Parveen, Wahle, Klaus W.J, Calder, Philip C
Format: Article
Language:English
Subjects:
Adiponectin - blood
Adolescent
Adult
Aged
Aged, 80 and over
Aging
Aging - blood
Aging - immunology
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure
Body Mass Index
Cardiology. Vascular system
Cardiovascular
Cardiovascular disease
Cardiovascular system
Cell Adhesion Molecules - blood
Chemokine
Cholesterol - blood
Cross-Sectional Studies
Cytokines - blood
Humans
Inflammation
Inflammation - blood
Inflammation - physiopathology
Male
Medical sciences
Middle Aged
Miscellaneous
Pharmacology. Drug treatments
Soluble adhesion molecule
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Summary:Abstract Objective To examine whether age-related increase in concentrations of circulating inflammatory mediators is due to concurrent increases in cardiovascular risk factors or is independent of these. Methods and results Cytokines (IL-6, IL-18), chemokines (6Ckine, MCP-1, IP-10), soluble adhesion molecules (sICAM-1, sVCAM-1, sE-selectin) and adipokines (adiponectin) were measured in the plasma of healthy male subjects aged 18–84 years ( n = 162). These were related to known cardiovascular risk factors (age, BMI, systolic and diastolic blood pressure, plasma total cholesterol, LDL cholesterol, HDL cholesterol and triacylglycerol concentrations) in order to identify significant associations. Plasma concentrations of sVCAM-1, sE-selectin, IL-6, IL-18, MCP-1, 6Ckine, IP-10 and adiponectin, but not sICAM-1, were significantly positively correlated with age, as well as with several other cardiovascular risk factors. The correlations with other risk factors disappeared when age was controlled for. In contrast, the correlations with age remained significant for sVCAM-1, IL-6, MCP-1, 6Ckine and IP-10 when other cardiovascular risk factors were controlled for. Conclusions Plasma concentrations of some inflammatory markers (sVCAM-1, IL-6, MCP-1, 6Ckine, IP-10) are positively correlated with age, independent of other cardiovascular risk factors. This suggests that age-related inflammation may not be driven by recognised risk factors.
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2006.11.002