Capillary zone electrophoresis for separation and analysis of hydroxycitric acid and hydroxycitric acid lactone: Application to herbal products of Garcinia atroviridis Griff

Capillary zone electrophoresis (CZE) was developed for quantitative determination of hydroxycitric acid and hydroxycitric acid lactone in herbal products of Garcinia atroviridis Griff. Resolution optimization was investigated by varying type, concentration and pH of buffers. Using the pH 9.2 buffer...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 2008-02, Vol.46 (3), p.577-582
Main Authors: Muensritharam, Laksamee, Tolieng, Vasana, Chaichantipyuth, Chaiyo, Petsom, Amorn, Nhujak, Thumnoon
Format: Article
Language:English
Subjects:
Analysis
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Capillary electrophoresis
Carboxylic acids
Citrates - analysis
Electrophoresis, Capillary - methods
Fundamental and applied biological sciences. Psychology
Garcinia - chemistry
Garcinia atroviridis Griff
General pharmacology
Hydrogen-Ion Concentration
Hydroxycarboxylic acid
Hydroxycitric acid
Lactones - analysis
Medical sciences
Pharmacology. Drug treatments
Plant Preparations - chemistry
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Summary:Capillary zone electrophoresis (CZE) was developed for quantitative determination of hydroxycitric acid and hydroxycitric acid lactone in herbal products of Garcinia atroviridis Griff. Resolution optimization was investigated by varying type, concentration and pH of buffers. Using the pH 9.2 buffer containing 30 mM Na 2B 4O 7, 90 mM NaH 2PO 4 and 0.5 mM tetradecyltrimethyl ammonium bromide, baseline resolution ( R s > 1.5) was found for all analytes. Advantages of the developed CZE method include simple sample preparation, fast analysis time within 5 min and high accuracy and precision.
ISSN:0731-7085
1873-264X
DOI:10.1016/j.jpba.2007.11.008