In vitro antimalarial activity of flavonoid derivatives dehydrosilybin and 8-(1;1)-DMA-kaempferide

Multidrug-resistant Plasmodium falciparum strains are an increasing problem in endemic areas and are partly responsible for the worsening malaria situation around the world. New cheap and effective compounds active in combination with available drug in the field are urgently needed. The aim of this...

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Bibliographic Details
Published in:Acta tropica 2006, Vol.97 (1), p.102-107
Main Authors: Monbrison, Frédérique de, Maitrejean, Mathias, Latour, Christine, Bugnazet, Franck, Peyron, François, Barron, Denis, Picot, Stephane
Format: Article
Language:English
Subjects:
Animals
Antimalarial drugs
Antimalarials - chemistry
Antimalarials - pharmacology
Biological and medical sciences
Chloroquine - pharmacology
Dehydrosilybin
DMA-kaempferide
Dose-Response Relationship, Drug
Drug Resistance
Flavonoid
Flavonoids - chemistry
Flavonoids - pharmacology
General aspects
Humans
Kaempferols - chemistry
Kaempferols - pharmacology
Medical sciences
Parasitic Sensitivity Tests
Plasmodium falciparum
Plasmodium falciparum - drug effects
Plasmodium falciparum - growth & development
Silymarin - chemistry
Silymarin - pharmacology
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Summary:Multidrug-resistant Plasmodium falciparum strains are an increasing problem in endemic areas and are partly responsible for the worsening malaria situation around the world. New cheap and effective compounds active in combination with available drug in the field are urgently needed. The aim of this work was to explore the potential antiplasmodial effect of flavonoid derivatives on parasites growth in vitro. In vitro antiplasmodial activity of dehydrosilybin and 8-(1;1)-DMA-kaempferide has been evaluated by real time PCR for five P. falciparum strains. Both revealed significative antimalarial activity against the different strains. Since this drug family has been largely used and well-tolerated in humans, flavonoid derivatives could be in the near future associated with already available drugs in order to delay the spread of P. falciparum resistance.
ISSN:0001-706X
1873-6254
DOI:10.1016/j.actatropica.2005.09.004