A 5–7 year in vivo study of high-strength hydroxyapatite/poly( l-lactide) composite rods for the internal fixation of bone fractures

The biocompatibility and biodegradation of hydroxyapatite (HA)/poly( l-lactide) (PLLA) composite bone implant rods were studied using two types of HA particles as reinforcing fillers, uncalcined-HA (u-HA) or calcined-HA (c-HA). Composite rods of u-HA/PLLA and c-HA/PLLA were implanted into the distal...

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Bibliographic Details
Published in:Biomaterials 2006-03, Vol.27 (8), p.1327-1332
Main Authors: Hasegawa, Shin, Ishii, Shinsuke, Tamura, Jiro, Furukawa, Taizo, Neo, Masashi, Matsusue, Yoshitaka, Shikinami, Yasuo, Okuno, Masaki, Nakamura, Takashi
Format: Article
Language:English
Subjects:
Animal model
Animals
Biodegradation
Bioresorption
Bone Substitutes
Composite
Durapatite
Femoral Fractures - surgery
Fracture Fixation, Internal - instrumentation
Hydroxyapatite
Internal Fixators
Male
PLLA
Polyesters
Prostheses and Implants
Rabbits
Time Factors
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Summary:The biocompatibility and biodegradation of hydroxyapatite (HA)/poly( l-lactide) (PLLA) composite bone implant rods were studied using two types of HA particles as reinforcing fillers, uncalcined-HA (u-HA) or calcined-HA (c-HA). Composite rods of u-HA/PLLA and c-HA/PLLA were implanted into the distal femurs of 25 rabbits. Four of these rabbits lived for more than 5 years after implantation, with one living for 7 years 4 months. Samples were retrieved after the rabbits died naturally and specimens were examined by light microscopy and scanning electron microscopy (SEM). For u-HA/PLLA, the shrinkage of the rods progressed further after 4 years, and some were almost completely resorbed. We could not find traces of the rod in some sections from more than 6 years. Remodeled bone encircled the residual material, and trabecular bone bonded directly to the rod was found toward the center. For u-HA/PLLA 30%, results were similar to u-HA/PLLA 40%, and the cross-sectional area had decreased by 4.0% at over 7 years. Most of the PLLA had been released from the rods. Neither obvious osteolytic nor osteoarthritic changes were found after 4 years.
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2005.09.003