An Engineered Virus as a Scaffold for Three-Dimensional Self-Assembly on the Nanoscale

Exquisite control over positioning nanoscale components on a protein scaffold allows bottom‐up self‐assembly of nanodevices. Using cowpea mosaic virus, modified to express cysteine residues on the capsid exterior, gold nanoparticles were attached to the viral scaffold to produce specific interpartic...

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2005-07, Vol.1 (7), p.702-706
Main Authors: Blum, Amy Szuchmacher, Soto, Carissa M., Wilson, Charmaine D., Brower, Tina L., Pollack, Steven K., Schull, Terence L., Chatterji, Anju, Lin, Tianwei, Johnson, John E., Amsinck, Christian, Franzon, Paul, Shashidhar, Ranganathan, Ratna, Banahalli R.
Format: Article
Language:English
Subjects:
Biomedical Engineering - methods
Capsid - chemistry
Electronics
Microscopy, Scanning Tunneling
Models, Chemical
Models, Molecular
molecular electronics
Mutation
Nanocomposites - chemistry
Nanostructures
nanotechnology
Nanotechnology - methods
protein engineering
Protein Engineering - methods
self-assembly
viruses
Viruses - chemistry
Viruses - genetics
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Summary:Exquisite control over positioning nanoscale components on a protein scaffold allows bottom‐up self‐assembly of nanodevices. Using cowpea mosaic virus, modified to express cysteine residues on the capsid exterior, gold nanoparticles were attached to the viral scaffold to produce specific interparticle distances (see picture). The nanoparticles were then interconnected using thiol‐terminated conjugated organic molecules that act as “molecular wires”, resulting in a 3D spherical conductive network, which is only 30 nm in diameter.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.200500021