Distinctive MicroRNA Profiles Relating to Patient Survival in Esophageal Squamous Cell Carcinoma

Esophageal cancer is the sixth leading cause of death from cancer and one of the least studied cancers worldwide. The global microRNA expression profile of esophageal cancer has not been reported previously. Here, for the first time, we have investigated expressed microRNAs in cryopreserved esophage...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 2008, Vol.68 (1), p.26-33
Main Authors: YONG GUO, ZHAOLI CHEN, KANG SHAO, NING LI, BIN QIU, MITCHELSON, Keith, JING CHENG, JIE HE, LIANG ZHANG, FANG ZHOU, SUSHENG SHI, XIAOLI FENG, BAOZHONG LI, XIN MENG, XI MA, MINGYONG LUO
Format: Article
Language:English
Subjects:
Adult
Antineoplastic agents
Biological and medical sciences
Carcinoma, Squamous Cell - diagnosis
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - pathology
Esophageal Neoplasms - diagnosis
Esophageal Neoplasms - mortality
Esophageal Neoplasms - pathology
Esophagus
Female
Gastroenterology. Liver. Pancreas. Abdomen
Gene Expression Profiling
Humans
Male
Medical sciences
MicroRNAs - analysis
MicroRNAs - genetics
Middle Aged
Oligonucleotide Array Sequence Analysis
Pharmacology. Drug treatments
Prognosis
Reverse Transcriptase Polymerase Chain Reaction
Survival Analysis
Tumors
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Summary:Esophageal cancer is the sixth leading cause of death from cancer and one of the least studied cancers worldwide. The global microRNA expression profile of esophageal cancer has not been reported previously. Here, for the first time, we have investigated expressed microRNAs in cryopreserved esophageal cancer tissues using advanced microRNA microarray techniques. Our microarray analyses identified seven microRNAs that could distinguish malignant esophageal cancer lesions from adjacent normal tissues. Some microRNAs could be correlated with the different clinicopathologic classifications. High expression of hsa-miR-103/107 correlated with poor survival by univariate analysis as well as by multivariate analysis. These results indicate that microRNA expression profiles are important diagnostic and prognostic markers of esophageal cancer, which might be analyzed simply using economical approaches such as reverse transcription-PCR.
ISSN:0008-5472
1538-7445
DOI:10.1158/0008-5472.can-06-4418