Costs of Intravenous Adverse Drug Events in Academic and Nonacademic Intensive Care Units

Background: Adverse drug events (ADEs), particularly those involving intravenous medications (IV-ADEs), are common among intensive care unit (ICU) patients and may increase hospitalization costs. Precise cost estimates have not been reported for academic ICUs, and no studies have included nonacademi...

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Bibliographic Details
Published in:Medical care 2008-01, Vol.46 (1), p.17-24
Main Authors: Nuckols, Teryl K., Paddock, Susan M., Bower, Anthony G., Rothschild, Jeffrey M., Fairbanks, Rollin J., Carlson, Beverly, Panzer, Robert J., Hilborne, Lee H.
Format: Article
Language:English
Subjects:
Academic Medical Centers
Aged
APACHE
Case-Control Studies
Cost control
Cost estimates
Drug-Related Side Effects and Adverse Reactions
Economics, Hospital
Female
Health care costs
Health care expenditures
Hospital admissions
Hospital costs
Hospital units
Hospitalization
Hospitals
Hospitals, Teaching - economics
Humans
Infusions, Intravenous
Injections, Intravenous
Intensive care
Intensive care units
Intensive Care Units - economics
Length of stay
Length of Stay - economics
Male
Medication Errors
Medications
Middle Aged
Pharmaceutical Preparations - administration & dosage
Pharmaceutical Preparations - economics
Studies
Total costs
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Summary:Background: Adverse drug events (ADEs), particularly those involving intravenous medications (IV-ADEs), are common among intensive care unit (ICU) patients and may increase hospitalization costs. Precise cost estimates have not been reported for academic ICUs, and no studies have included nonacademic ICUs. Objectives: To estimate increases in costs and length of stay after IV-ADEs at an academic and a nonacademic hospital. Research Design: This study reviewed medical records to identify IV-ADEs, and then, using a nested case-control design with propensity-score matching, assessed differences in costs and length of stay between cases and controls. Subjects: A total of 4604 adult ICU patients in 3 ICUs at an academic hospital and 2 ICUs at a nonacademic hospital in 2003 and 2004. Measures: Increased cost and length of stay associated with IVADEs. Results: Three hundred ninety-seven IV-ADEs were identified: 79% temporary physical injuries, 0% permanent physical injuries, 20% interventions to sustain life, and 2% in-hospital deaths. In the academic ICUs, patients with IV-ADEs had $6647 greater costs (P < 0.0001) and 4.8-day longer stays (P = 0.0003) compared with controls. In the nonacademic ICUs, IV-ADEs were not associated with greater costs ($188, P = 0.4236) or lengths of stay (-0.3 days, P = 0.8016). Cost and length-of-stay differences between the hospitals were statistically significant (P = 0.0012). However, there were no differences in IV-ADE severity or preventability, and the characteristics of patients experiencing IV-ADEs differed only modestly. Conclusions: IV-ADEs substantially increased hospitalization costs and length of stay in ICUs at an academic hospital but not at a nonacademic hospital, likely because of differences in practices after IV-ADEs occurred.
ISSN:0025-7079
1537-1948
DOI:10.1097/MLR.0b013e3181589bed