Chronic renal failure and growth hormone: effects on GH-IGF axis and leptin

To analyze the changes in IGF-1, IGFBP-3, leptin and insulin after replacement doses of recombinant human growth hormone (rhGH) in short prepubertal children with chronic renal failure (CRF). Eleven children (3F:8M), with mean age of 9.6 years, were treated with rhGH (0.23 mg/Kg weekly for 12 months...

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Published in:Arquivos brasileiros de endocrinologia e metabologia 2005-12, Vol.49 (6), p.964-970
Main Authors: Oliveira, Josenilson C de, Machado Neto, Francisco de A, Morcillo, André Moreno, Oliveira, Laurione C de, Belangero, Vera Maria S, Geloneze Neto, Bruno, Tambascia, Marcos Antonio, Guerra-Júnior, Gil
Format: Article
Language:Portuguese
Subjects:
Body Composition
Body Height - drug effects
Body Height - physiology
Child
Electric Impedance
Enzyme-Linked Immunosorbent Assay
Female
Hormone Replacement Therapy
Human Growth Hormone - metabolism
Human Growth Hormone - therapeutic use
Humans
Insulin - blood
Insulin-Like Growth Factor Binding Protein 3 - blood
Insulin-Like Growth Factor I - analysis
Kidney Failure, Chronic - blood
Kidney Failure, Chronic - drug therapy
Kidney Failure, Chronic - physiopathology
Leptin - blood
Male
Statistics, Nonparametric
Time Factors
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Summary:To analyze the changes in IGF-1, IGFBP-3, leptin and insulin after replacement doses of recombinant human growth hormone (rhGH) in short prepubertal children with chronic renal failure (CRF). Eleven children (3F:8M), with mean age of 9.6 years, were treated with rhGH (0.23 mg/Kg weekly for 12 months). Serum leptin, insulin, glucose, IGF-1 and IGFBP-3 were measured before, 6 and 12 months after beginning rhGH treatment. The serum levels of leptin, insulin and glucose did not vary during the treatment; normal leptin and glucose levels and high insulin were observed. There was a significant increment of IGF-1 and IGFBP-3 during the use of rhGH. The replacement doses of rhGH during 12 months in a selected group of CRF children determined an increment in IGF-1 and IGFBP-3, associated to normal serum leptin and insulin resistance.
ISSN:0004-2730
1677-9487