Dietary Selenium for the counteraction of oxidative damage: fortified foods or supplements?

Since any significant modification in the Se status, leading to changes in the activity of the seleno-enzymes, may have important consequences on the susceptibility of tissues to oxidative stress, considerable efforts have been made upon increasing Se dietary intake. In this respect, an important de...

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Bibliographic Details
Published in:British journal of nutrition 2008-01, Vol.99 (1), p.191-197
Main Authors: Bordoni, Alessandra, Danesi, Francesca, Malaguti, Marco, Di Nunzio, Mattia, Pasqui, Francesca, Maranesi, Magda, Luigi Biagi, Pier
Format: Article
Language:English
Subjects:
animal models
Animals
antioxidant activity
Antioxidants - administration & dosage
Antioxidants - analysis
bioavailability
Biological Availability
Biomarkers - blood
Comparative studies
dietary mineral supplements
dietary minerals
Dietary Supplements
enzyme activity
Fatty Acids - analysis
Food, Fortified
fortified foods
Functional foods & nutraceuticals
Glutathione - analysis
glutathione peroxidase
Glutathione Peroxidase - analysis
Glutathione Peroxidase - blood
intestinal absorption
Lipids - analysis
Lipids - chemistry
liver
Liver - chemistry
Liver - metabolism
Male
nutrient intake
Nutrition research
nutritional status
Oxidation-Reduction
Oxidative stress
Random Allocation
Rats
Rats, Wistar
Reactive Oxygen Species - blood
Selenium
Selenium - administration & dosage
Selenium - blood
Selenium-enriched food
Sodium selenite
Sodium Selenite - administration & dosage
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Summary:Since any significant modification in the Se status, leading to changes in the activity of the seleno-enzymes, may have important consequences on the susceptibility of tissues to oxidative stress, considerable efforts have been made upon increasing Se dietary intake. In this respect, an important debate is still open about the bioavailability and the effectiveness of Se, and more generally nutrients, in supplements compared with foods. Using male Wistar rats, we have compared the effectiveness of two different diets in which an adequate Se content (0·1 mg/kg) was achieved by adding the element as sodium selenite or as component of a lyophilized Se-enriched food, in the counteraction of an oxidative stress induced by intraperitoneal administration of adriamycin. Both Se-enriched diets were able to reduce the consequences of the oxidative stress in liver, mainly by increasing glutathione peroxidase activity. This increase was more evident in rats fed on the diet enriched with the lyophilized food, probably due to the different chemical forms of Se, or to other components of the food itself. Although further studies are needed, data herein presented may contribute to the characterization of the effectiveness of Se from different sources, foods or supplements, in the light of dietary advice to the population concerning improvement of Se intake.
ISSN:0007-1145
1475-2662
DOI:10.1017/S0007114507793911