Analysis of Prognostic Factors Influencing Long-term Survival After Hepatic Resection for Metastatic Colorectal Cancer

Background The aim of this study was to analyze the prognostic factors associated with long-term outcome after liver resection for colorectal metastases. The retrospective analysis included 297 liver resections for colorectal metastases. Methods The variables considered included disease stage, diffe...

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Bibliographic Details
Published in:World journal of surgery 2008-01, Vol.32 (1), p.93-103
Main Authors: Arru, Marcella, Aldrighetti, Luca, Castoldi, Renato, Di Palo, Saverio, Orsenigo, Elena, Stella, Marco, Pulitanò, Carlo, Gavazzi, Francesca, Ferla, Gianfranco, Di Carlo, Valerio, Staudacher, Carlo
Format: Article
Language:English
Subjects:
Abdominal Surgery
Aged
Biological and medical sciences
Cardiac Surgery
Clinical Risk Score
Colorectal cancer
Colorectal Neoplasms - pathology
Colorectal Tumor
Female
General aspects
General Surgery
Hepatectomy
Humans
Liver Metastasis
Liver Neoplasms - secondary
Liver Neoplasms - surgery
Liver Resection
Liver, biliary tract, pancreas, portal circulation, spleen
Male
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Postoperative Complications
Prognosis
Proportional Hazards Models
Resection Margin
Retrospective Studies
Risk Factors
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the digestive system
Survival Analysis
Thoracic Surgery
Treatment Outcome
Vascular Surgery
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Summary:Background The aim of this study was to analyze the prognostic factors associated with long-term outcome after liver resection for colorectal metastases. The retrospective analysis included 297 liver resections for colorectal metastases. Methods The variables considered included disease stage, differentiation grade, site and nodal metastasis of the primary tumor, number and diameter of the lesions, time from primary cancer to metastasis, preoperative carcinoembryonic antigen (CEA) level, adjuvant chemotherapy, type of resection, intraoperative ultrasonography and portal clamping use, blood loss, transfusions, complications, hospitalization, surgical margins status, and a clinical risk score (MSKCC-CRS). Results The univariate analysis revealed a significant difference ( p < 0.05) in overall 5-year survival rates depending on the differentiation grade, preoperative CEA >5 and >200 ng/ml, diameter of the lesion >5 cm, time from primary tumor to metastases >12 months, MSKCC-CRS >2. The multivariate analysis showed three independent negative prognostic factors: G3 or G4 grade, CEA >5 ng/ml, and high MSKCC-CRS. Conclusions No single prognostic factor proved to be associated with a sufficiently disappointing outcome to exclude patients from liver resection. However, in the presence of some prognostic factors (G3–G4 differentiation, preoperative CEA >5 ng/ml, high MSKCC-CRS), enrollment of patients in trials exploring new adjuvant treatments is suggested to improve the outcome after surgery.
ISSN:0364-2313
1432-2323
DOI:10.1007/s00268-007-9285-y