Presence of cortisol in gingival crevicular fluid A pilot study

. Cortisol is one of the primary mediators of the stress response, in the main having immunosuppressive effects. An important component of the host response in periodontal inflammation is gingival crevicular fluid (GCF), with constituents mainly derived from serum, Cortisol like many other steroids,...

Full description

Saved in:
Bibliographic Details
Published in:Journal of clinical periodontology 1998-11, Vol.25 (11), p.929-932
Main Authors: Axtelius, B., Edwardsson, S., Theodorsson, E., Svensäter, G., Attström, R.
Format: Article
Language:English
Subjects:
Adult
Aged
cortisol
Dentistry
Female
gingival crevicular fluid
Gingival Crevicular Fluid - chemistry
Humans
Hydrocortisone - analysis
Male
Middle Aged
Periodontal Pocket - metabolism
periodontitis
Pilot Projects
Radioimmunoassay - methods
stress
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:. Cortisol is one of the primary mediators of the stress response, in the main having immunosuppressive effects. An important component of the host response in periodontal inflammation is gingival crevicular fluid (GCF), with constituents mainly derived from serum, Cortisol like many other steroids, is present in saliva but its occurrence in GCF does not seem to be documented, Unstimulated whole saliva was collected and GCF was sampled on filter disks. The samples were analysed by a modified RIA method for serum in such a way that small volumes and low concentrations could be measured. Our findings suggest that the total concentration of cortisol in GCF might be estimated to levels below 1/10 of that in serum. However, what appears as a distinctive feature is the considerable variation of the cortisol concentrations for individual teeth. To our knowledge, this is the first time cortisol has been measured in gingival crevicular fluid, and this opens Ihe prospects for further in vivo research.
ISSN:0303-6979
1600-051X
DOI:10.1111/j.1600-051X.1998.tb02392.x