Loading…
Clinicopathological profile and long-term outcome in young adults with gastric cancer: multicenter evaluation of 214 patients
Background and aims Gastric cancer (GC) is usually diagnosed in the sixth and seventh decade of life, although it may also be found in younger patients. The aim of this study was to analyse the potential differences in demographic and clinicopathological factors between the younger (40 years of age...
Saved in:
| Published in: | Langenbeck's archives of surgery 2008-01, Vol.393 (1), p.37-43 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c342t-3efee3f64c36ca99389289baab9eacb4562a8ffd09f601416200ff391ebd07d93 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c342t-3efee3f64c36ca99389289baab9eacb4562a8ffd09f601416200ff391ebd07d93 |
| container_end_page | 43 |
| container_issue | 1 |
| container_start_page | 37 |
| container_title | Langenbeck's archives of surgery |
| container_volume | 393 |
| creator | Kulig, Jan Popiela, Tadeusz Kolodziejczyk, Piotr Sierzega, Marek Jedrys, Joanna Szczepanik, Antoni M. |
| description | Background and aims
Gastric cancer (GC) is usually diagnosed in the sixth and seventh decade of life, although it may also be found in younger patients. The aim of this study was to analyse the potential differences in demographic and clinicopathological factors between the younger (40 years of age and less) and older (above 40 years) population of GC.
Materials and methods
An electronic database covering all gastric cancer patients treated between 1977 and 1998 at eight university surgical centres was reviewed.
Results
Of 3,431 patients treated, 214 (6.2%) were 40 years of age or younger. No differences in tumour staging or location could be identified, but the diffuse type lesions were more common in the younger patients (52.6 vs 29.8%). No differences were found in morbidity and mortality rates, except a higher incidence of cardiopulmonary complications in older patients undergoing stomach resection (6.6 vs 12.3%). Median survival of patients after gastrectomy was 24.7 months (95% confidence interval [CI] 22.7–26.6) and was insignificantly longer in younger (30.8 months, 95%CI 21.0–40.5) than older (24.1 months, 95%CI 22.1–26.1) patients (
P
= 0.056). Median survival for unresectable cases was 5.4 months (95%CI 5.1–5.7) and was comparable in the younger (median 5.5 months, 95%CI 5.2–5.8) and older (median 4.4 months, 95%CI 3.7–5.1) groups.
Conclusion
GC in young adults demonstrates only minor deviations from the general population with a similar long-term outcome. |
| doi_str_mv | 10.1007/s00423-007-0208-z |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70098881</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70098881</sourcerecordid><originalsourceid>FETCH-LOGICAL-c342t-3efee3f64c36ca99389289baab9eacb4562a8ffd09f601416200ff391ebd07d93</originalsourceid><addsrcrecordid>eNp9kEuLFDEUhYMozkN_gBvJyl3pzaOrKu6k8TEw4EbXIZW6qcmQStokpcyA_9003ejOVQ6c75xwDyGvGLxlAMO7AiC56JrsgMPYPT4hl0yKXcfljj39q6W4IFel3ANAPyj5nFywoWdjYy7J733w0dt0MPUuhbR4awI95OR8QGriTEOKS1cxrzRt1aYVqY_0IW1xoWbeQi30l693dDGlZm-pNdFifk_XZnmLsSUp_jRhM9WnSJOjnEnafvPNKy_IM2dCwZfn95p8__Tx2_5Ld_v1883-w21nheS1E-gQheulFb01SolR8VFNxkwKjZ3krudmdG4G5XpgkvUcwDmhGE4zDLMS1-TNqbdd9mPDUvXqi8UQTMS0FT0AqHEcWQPZCbQ5lZLR6UP2q8kPmoE-bq5Pm-ujPG6uH1vm9bl8m1ac_yXOIzeAn4DSrLhg1vdpy7Ed_J_WPzsPj9g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70098881</pqid></control><display><type>article</type><title>Clinicopathological profile and long-term outcome in young adults with gastric cancer: multicenter evaluation of 214 patients</title><source>Springer Nature:Jisc Collections:Springer Nature Read and Publish 2023-2025: Springer Reading List</source><creator>Kulig, Jan ; Popiela, Tadeusz ; Kolodziejczyk, Piotr ; Sierzega, Marek ; Jedrys, Joanna ; Szczepanik, Antoni M.</creator><creatorcontrib>Kulig, Jan ; Popiela, Tadeusz ; Kolodziejczyk, Piotr ; Sierzega, Marek ; Jedrys, Joanna ; Szczepanik, Antoni M. ; Polish Gastric Cancer Study Group ; on behalf of the Polish Gastric Cancer Study Group</creatorcontrib><description>Background and aims
Gastric cancer (GC) is usually diagnosed in the sixth and seventh decade of life, although it may also be found in younger patients. The aim of this study was to analyse the potential differences in demographic and clinicopathological factors between the younger (40 years of age and less) and older (above 40 years) population of GC.
Materials and methods
An electronic database covering all gastric cancer patients treated between 1977 and 1998 at eight university surgical centres was reviewed.
Results
Of 3,431 patients treated, 214 (6.2%) were 40 years of age or younger. No differences in tumour staging or location could be identified, but the diffuse type lesions were more common in the younger patients (52.6 vs 29.8%). No differences were found in morbidity and mortality rates, except a higher incidence of cardiopulmonary complications in older patients undergoing stomach resection (6.6 vs 12.3%). Median survival of patients after gastrectomy was 24.7 months (95% confidence interval [CI] 22.7–26.6) and was insignificantly longer in younger (30.8 months, 95%CI 21.0–40.5) than older (24.1 months, 95%CI 22.1–26.1) patients (
P
= 0.056). Median survival for unresectable cases was 5.4 months (95%CI 5.1–5.7) and was comparable in the younger (median 5.5 months, 95%CI 5.2–5.8) and older (median 4.4 months, 95%CI 3.7–5.1) groups.
Conclusion
GC in young adults demonstrates only minor deviations from the general population with a similar long-term outcome.</description><identifier>ISSN: 1435-2443</identifier><identifier>EISSN: 1435-2451</identifier><identifier>DOI: 10.1007/s00423-007-0208-z</identifier><identifier>PMID: 17618451</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Abdominal Surgery ; Adenocarcinoma - mortality ; Adenocarcinoma - pathology ; Adenocarcinoma - surgery ; Adult ; Age Factors ; Cardiac Surgery ; Disease-Free Survival ; Female ; Follow-Up Studies ; Gastrectomy ; General Surgery ; Humans ; Kaplan-Meier Estimate ; Lymph Node Excision ; Lymphatic Metastasis ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Original Article ; Pancreatectomy ; Retrospective Studies ; Splenectomy ; Stomach - pathology ; Stomach Neoplasms - mortality ; Stomach Neoplasms - pathology ; Stomach Neoplasms - surgery ; Thoracic Surgery ; Traumatic Surgery ; Vascular Surgery ; Young Adult</subject><ispartof>Langenbeck's archives of surgery, 2008-01, Vol.393 (1), p.37-43</ispartof><rights>Springer-Verlag 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-3efee3f64c36ca99389289baab9eacb4562a8ffd09f601416200ff391ebd07d93</citedby><cites>FETCH-LOGICAL-c342t-3efee3f64c36ca99389289baab9eacb4562a8ffd09f601416200ff391ebd07d93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17618451$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kulig, Jan</creatorcontrib><creatorcontrib>Popiela, Tadeusz</creatorcontrib><creatorcontrib>Kolodziejczyk, Piotr</creatorcontrib><creatorcontrib>Sierzega, Marek</creatorcontrib><creatorcontrib>Jedrys, Joanna</creatorcontrib><creatorcontrib>Szczepanik, Antoni M.</creatorcontrib><creatorcontrib>Polish Gastric Cancer Study Group</creatorcontrib><creatorcontrib>on behalf of the Polish Gastric Cancer Study Group</creatorcontrib><title>Clinicopathological profile and long-term outcome in young adults with gastric cancer: multicenter evaluation of 214 patients</title><title>Langenbeck's archives of surgery</title><addtitle>Langenbecks Arch Surg</addtitle><addtitle>Langenbecks Arch Surg</addtitle><description>Background and aims
Gastric cancer (GC) is usually diagnosed in the sixth and seventh decade of life, although it may also be found in younger patients. The aim of this study was to analyse the potential differences in demographic and clinicopathological factors between the younger (40 years of age and less) and older (above 40 years) population of GC.
Materials and methods
An electronic database covering all gastric cancer patients treated between 1977 and 1998 at eight university surgical centres was reviewed.
Results
Of 3,431 patients treated, 214 (6.2%) were 40 years of age or younger. No differences in tumour staging or location could be identified, but the diffuse type lesions were more common in the younger patients (52.6 vs 29.8%). No differences were found in morbidity and mortality rates, except a higher incidence of cardiopulmonary complications in older patients undergoing stomach resection (6.6 vs 12.3%). Median survival of patients after gastrectomy was 24.7 months (95% confidence interval [CI] 22.7–26.6) and was insignificantly longer in younger (30.8 months, 95%CI 21.0–40.5) than older (24.1 months, 95%CI 22.1–26.1) patients (
P
= 0.056). Median survival for unresectable cases was 5.4 months (95%CI 5.1–5.7) and was comparable in the younger (median 5.5 months, 95%CI 5.2–5.8) and older (median 4.4 months, 95%CI 3.7–5.1) groups.
Conclusion
GC in young adults demonstrates only minor deviations from the general population with a similar long-term outcome.</description><subject>Abdominal Surgery</subject><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma - surgery</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Cardiac Surgery</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastrectomy</subject><subject>General Surgery</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Lymph Node Excision</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>Original Article</subject><subject>Pancreatectomy</subject><subject>Retrospective Studies</subject><subject>Splenectomy</subject><subject>Stomach - pathology</subject><subject>Stomach Neoplasms - mortality</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach Neoplasms - surgery</subject><subject>Thoracic Surgery</subject><subject>Traumatic Surgery</subject><subject>Vascular Surgery</subject><subject>Young Adult</subject><issn>1435-2443</issn><issn>1435-2451</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNp9kEuLFDEUhYMozkN_gBvJyl3pzaOrKu6k8TEw4EbXIZW6qcmQStokpcyA_9003ejOVQ6c75xwDyGvGLxlAMO7AiC56JrsgMPYPT4hl0yKXcfljj39q6W4IFel3ANAPyj5nFywoWdjYy7J733w0dt0MPUuhbR4awI95OR8QGriTEOKS1cxrzRt1aYVqY_0IW1xoWbeQi30l693dDGlZm-pNdFifk_XZnmLsSUp_jRhM9WnSJOjnEnafvPNKy_IM2dCwZfn95p8__Tx2_5Ld_v1883-w21nheS1E-gQheulFb01SolR8VFNxkwKjZ3krudmdG4G5XpgkvUcwDmhGE4zDLMS1-TNqbdd9mPDUvXqi8UQTMS0FT0AqHEcWQPZCbQ5lZLR6UP2q8kPmoE-bq5Pm-ujPG6uH1vm9bl8m1ac_yXOIzeAn4DSrLhg1vdpy7Ed_J_WPzsPj9g</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Kulig, Jan</creator><creator>Popiela, Tadeusz</creator><creator>Kolodziejczyk, Piotr</creator><creator>Sierzega, Marek</creator><creator>Jedrys, Joanna</creator><creator>Szczepanik, Antoni M.</creator><general>Springer-Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080101</creationdate><title>Clinicopathological profile and long-term outcome in young adults with gastric cancer: multicenter evaluation of 214 patients</title><author>Kulig, Jan ; Popiela, Tadeusz ; Kolodziejczyk, Piotr ; Sierzega, Marek ; Jedrys, Joanna ; Szczepanik, Antoni M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-3efee3f64c36ca99389289baab9eacb4562a8ffd09f601416200ff391ebd07d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Abdominal Surgery</topic><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma - surgery</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Cardiac Surgery</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastrectomy</topic><topic>General Surgery</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Lymph Node Excision</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>Original Article</topic><topic>Pancreatectomy</topic><topic>Retrospective Studies</topic><topic>Splenectomy</topic><topic>Stomach - pathology</topic><topic>Stomach Neoplasms - mortality</topic><topic>Stomach Neoplasms - pathology</topic><topic>Stomach Neoplasms - surgery</topic><topic>Thoracic Surgery</topic><topic>Traumatic Surgery</topic><topic>Vascular Surgery</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kulig, Jan</creatorcontrib><creatorcontrib>Popiela, Tadeusz</creatorcontrib><creatorcontrib>Kolodziejczyk, Piotr</creatorcontrib><creatorcontrib>Sierzega, Marek</creatorcontrib><creatorcontrib>Jedrys, Joanna</creatorcontrib><creatorcontrib>Szczepanik, Antoni M.</creatorcontrib><creatorcontrib>Polish Gastric Cancer Study Group</creatorcontrib><creatorcontrib>on behalf of the Polish Gastric Cancer Study Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Langenbeck's archives of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kulig, Jan</au><au>Popiela, Tadeusz</au><au>Kolodziejczyk, Piotr</au><au>Sierzega, Marek</au><au>Jedrys, Joanna</au><au>Szczepanik, Antoni M.</au><aucorp>Polish Gastric Cancer Study Group</aucorp><aucorp>on behalf of the Polish Gastric Cancer Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinicopathological profile and long-term outcome in young adults with gastric cancer: multicenter evaluation of 214 patients</atitle><jtitle>Langenbeck's archives of surgery</jtitle><stitle>Langenbecks Arch Surg</stitle><addtitle>Langenbecks Arch Surg</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>393</volume><issue>1</issue><spage>37</spage><epage>43</epage><pages>37-43</pages><issn>1435-2443</issn><eissn>1435-2451</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Background and aims
Gastric cancer (GC) is usually diagnosed in the sixth and seventh decade of life, although it may also be found in younger patients. The aim of this study was to analyse the potential differences in demographic and clinicopathological factors between the younger (40 years of age and less) and older (above 40 years) population of GC.
Materials and methods
An electronic database covering all gastric cancer patients treated between 1977 and 1998 at eight university surgical centres was reviewed.
Results
Of 3,431 patients treated, 214 (6.2%) were 40 years of age or younger. No differences in tumour staging or location could be identified, but the diffuse type lesions were more common in the younger patients (52.6 vs 29.8%). No differences were found in morbidity and mortality rates, except a higher incidence of cardiopulmonary complications in older patients undergoing stomach resection (6.6 vs 12.3%). Median survival of patients after gastrectomy was 24.7 months (95% confidence interval [CI] 22.7–26.6) and was insignificantly longer in younger (30.8 months, 95%CI 21.0–40.5) than older (24.1 months, 95%CI 22.1–26.1) patients (
P
= 0.056). Median survival for unresectable cases was 5.4 months (95%CI 5.1–5.7) and was comparable in the younger (median 5.5 months, 95%CI 5.2–5.8) and older (median 4.4 months, 95%CI 3.7–5.1) groups.
Conclusion
GC in young adults demonstrates only minor deviations from the general population with a similar long-term outcome.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>17618451</pmid><doi>10.1007/s00423-007-0208-z</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1435-2443 |
| ispartof | Langenbeck's archives of surgery, 2008-01, Vol.393 (1), p.37-43 |
| issn | 1435-2443 1435-2451 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70098881 |
| source | Springer Nature:Jisc Collections:Springer Nature Read and Publish 2023-2025: Springer Reading List |
| subjects | Abdominal Surgery Adenocarcinoma - mortality Adenocarcinoma - pathology Adenocarcinoma - surgery Adult Age Factors Cardiac Surgery Disease-Free Survival Female Follow-Up Studies Gastrectomy General Surgery Humans Kaplan-Meier Estimate Lymph Node Excision Lymphatic Metastasis Male Medicine Medicine & Public Health Middle Aged Neoplasm Invasiveness Neoplasm Staging Original Article Pancreatectomy Retrospective Studies Splenectomy Stomach - pathology Stomach Neoplasms - mortality Stomach Neoplasms - pathology Stomach Neoplasms - surgery Thoracic Surgery Traumatic Surgery Vascular Surgery Young Adult |
| title | Clinicopathological profile and long-term outcome in young adults with gastric cancer: multicenter evaluation of 214 patients |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-21T14%3A12%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinicopathological%20profile%20and%20long-term%20outcome%20in%20young%20adults%20with%20gastric%20cancer:%20multicenter%20evaluation%20of%20214%20patients&rft.jtitle=Langenbeck's%20archives%20of%20surgery&rft.au=Kulig,%20Jan&rft.aucorp=Polish%20Gastric%20Cancer%20Study%20Group&rft.date=2008-01-01&rft.volume=393&rft.issue=1&rft.spage=37&rft.epage=43&rft.pages=37-43&rft.issn=1435-2443&rft.eissn=1435-2451&rft_id=info:doi/10.1007/s00423-007-0208-z&rft_dat=%3Cproquest_cross%3E70098881%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c342t-3efee3f64c36ca99389289baab9eacb4562a8ffd09f601416200ff391ebd07d93%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=70098881&rft_id=info:pmid/17618451&rfr_iscdi=true |