Clinicopathological profile and long-term outcome in young adults with gastric cancer: multicenter evaluation of 214 patients

Background and aims Gastric cancer (GC) is usually diagnosed in the sixth and seventh decade of life, although it may also be found in younger patients. The aim of this study was to analyse the potential differences in demographic and clinicopathological factors between the younger (40 years of age...

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Bibliographic Details
Published in:Langenbeck's archives of surgery 2008-01, Vol.393 (1), p.37-43
Main Authors: Kulig, Jan, Popiela, Tadeusz, Kolodziejczyk, Piotr, Sierzega, Marek, Jedrys, Joanna, Szczepanik, Antoni M.
Format: Article
Language:English
Subjects:
Abdominal Surgery
Adenocarcinoma - mortality
Adenocarcinoma - pathology
Adenocarcinoma - surgery
Adult
Age Factors
Cardiac Surgery
Disease-Free Survival
Female
Follow-Up Studies
Gastrectomy
General Surgery
Humans
Kaplan-Meier Estimate
Lymph Node Excision
Lymphatic Metastasis
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Invasiveness
Neoplasm Staging
Original Article
Pancreatectomy
Retrospective Studies
Splenectomy
Stomach - pathology
Stomach Neoplasms - mortality
Stomach Neoplasms - pathology
Stomach Neoplasms - surgery
Thoracic Surgery
Traumatic Surgery
Vascular Surgery
Young Adult
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Summary:Background and aims Gastric cancer (GC) is usually diagnosed in the sixth and seventh decade of life, although it may also be found in younger patients. The aim of this study was to analyse the potential differences in demographic and clinicopathological factors between the younger (40 years of age and less) and older (above 40 years) population of GC. Materials and methods An electronic database covering all gastric cancer patients treated between 1977 and 1998 at eight university surgical centres was reviewed. Results Of 3,431 patients treated, 214 (6.2%) were 40 years of age or younger. No differences in tumour staging or location could be identified, but the diffuse type lesions were more common in the younger patients (52.6 vs 29.8%). No differences were found in morbidity and mortality rates, except a higher incidence of cardiopulmonary complications in older patients undergoing stomach resection (6.6 vs 12.3%). Median survival of patients after gastrectomy was 24.7 months (95% confidence interval [CI] 22.7–26.6) and was insignificantly longer in younger (30.8 months, 95%CI 21.0–40.5) than older (24.1 months, 95%CI 22.1–26.1) patients ( P  = 0.056). Median survival for unresectable cases was 5.4 months (95%CI 5.1–5.7) and was comparable in the younger (median 5.5 months, 95%CI 5.2–5.8) and older (median 4.4 months, 95%CI 3.7–5.1) groups. Conclusion GC in young adults demonstrates only minor deviations from the general population with a similar long-term outcome.
ISSN:1435-2443
1435-2451
DOI:10.1007/s00423-007-0208-z