Flow cytometry in myelodysplastic syndromes: Report from a working conference

Abstract Since new therapeutic strategies are emerging in myelodysplastic syndromes (MDS), a refined diagnostic procedure of the several subgroups of MDS is of increased importance. Multidimensional flow cytometry may add significantly to a more detailed analysis of the hematopoietic lineages with r...

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Bibliographic Details
Published in:Leukemia research 2008-01, Vol.32 (1), p.5-17
Main Authors: Loken, Michael R, van de Loosdrecht, Arjan, Ogata, Kiyoyuki, Orfao, Alberto, Wells, Denise A
Format: Article
Language:English
Subjects:
Bone Marrow Cells - cytology
Cell Lineage
Criteria
Flow cytometry
Flow Cytometry - methods
Hematology, Oncology and Palliative Medicine
Humans
ICUS
Monocytes - cytology
Myelodysplastic syndromes
Myelodysplastic Syndromes - classification
Myelodysplastic Syndromes - diagnosis
Standardization
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Summary:Abstract Since new therapeutic strategies are emerging in myelodysplastic syndromes (MDS), a refined diagnostic procedure of the several subgroups of MDS is of increased importance. Multidimensional flow cytometry may add significantly to a more detailed analysis of the hematopoietic lineages with respect to qualification and quantification of bone marrow cells and is described in detail. Clearly defined aberrancies on myeloid immature and maturing cells are now identified with possible impact on diagnosis, classification and prognostication in the near feature.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2007.04.020