Nitric oxide-mediated anxiolytic-like and antidepressant-like effects in animal models of anxiety and depression

The effects of microinjection of the nitric oxide (NO) precursor l-arginine ( l-Arg), the NO synthase (NOS) inhibitors N-methyl- l-arginine ( l-NAME) and 7-nitroindazole (7-NI), and the cyclic guanosine 3',5'-monophosphate (cGMP) analog 8-Br-cGMP into the dorsal raphe nucleus (DRN) were as...

Full description

Saved in:
Bibliographic Details
Published in:Pharmacology, biochemistry and behavior biochemistry and behavior, 2008, Vol.88 (3), p.247-255
Main Authors: Spiacci, A., Kanamaru, F., Guimarães, F.S., Oliveira`, R.M.W.
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Animals
Anti-Anxiety Agents - pharmacology
Antidepressive Agents - pharmacology
Anxiety - physiopathology
Anxiety - psychology
Arginine - antagonists & inhibitors
Arginine - pharmacology
Biological and medical sciences
Depression
Depression - physiopathology
Depression - psychology
Dorsal raphe nucleus
Dose-Response Relationship, Drug
Elevated plus maze
Enzyme Inhibitors - pharmacology
Forced swim test
Indazoles - pharmacology
Male
Medical sciences
Mood disorders
Motor Activity - drug effects
Neuropharmacology
NG-Nitroarginine Methyl Ester - pharmacology
Nitric oxide
Nitric Oxide - physiology
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychopharmacology
Raphe Nuclei - drug effects
Raphe Nuclei - metabolism
Raphe Nuclei - physiology
Rats
Rats, Wistar
Swimming - psychology
Synaptic Transmission - drug effects
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effects of microinjection of the nitric oxide (NO) precursor l-arginine ( l-Arg), the NO synthase (NOS) inhibitors N-methyl- l-arginine ( l-NAME) and 7-nitroindazole (7-NI), and the cyclic guanosine 3',5'-monophosphate (cGMP) analog 8-Br-cGMP into the dorsal raphe nucleus (DRN) were assessed in rats using the elevated plus maze (EPM) and the forced swim test (FST). l-Arg (100 and 200 nmol) produced an anxiolytic-like effect in the EPM. 8-Br-cGMP (25 and 50 nmol) dose-dependently increased locomotor activity. In the FST, antidepressant-like effects were produced by l-Arg (50 and 100 nmol) and 8-Br-cGMP (12.5 and 25 nmol). Dual effects were observed with NOS inhibitors l-NAME and 7-NI in both the EPM and FST. While low doses of l-NAME (25 nmol) or 7-NI (1 nmol) induced a selective increase in EPM open arm exploration and a decrease in immobility time in the FST, high doses ( l-NAME 400 nmol, 7-NI 10 nmol) decreased locomotor activity. These results show that interference with NO-mediated neurotransmission in the DRN induced significant and complex motor and emotional effects. Further studies are needed to elucidate the mechanisms involved in these effects.
ISSN:0091-3057
1873-5177
DOI:10.1016/j.pbb.2007.08.008