Age-associated Inflammatory Changes: Role of Nutritional Intervention

Accumulating evidence suggests that aging is associated with dysregulated immune and inflammatory responses. Investigation into the cellular and molecular mechanisms underlying this phenomenon suggests that an up-regulated cyclooxygenase (COX)-2 expression, and resulting increase in production of pr...

Full description

Saved in:
Bibliographic Details
Published in:Nutrition reviews 2007-12, Vol.65 (12), p.S213-S216
Main Authors: Meydani, S.N, Wu, D
Format: Article
Language:English
Subjects:
Age
Aged
Aged, 80 and over
Aging
Aging - physiology
Alzheimer's disease
amides
biochemical mechanisms
Biological and medical sciences
ceramide
cyclooxygenase 2
Cyclooxygenase 2 - metabolism
Diet
Dinoprostone - metabolism
elderly
elderly nutrition
enzyme activity
Fundamental and applied biological sciences. Psychology
human health
human physiology
Humans
Immune system
immunity
Infectious diseases
Inflammation
Inflammation - enzymology
inflammatory response
literature reviews
macrophages
Molecular and cellular biology
Mortality
nuclear factor-kappa B
nutritional intervention
pathogenesis
prostaglandin E2
prostaglandin synthase
prostaglandins
risk factors
senescence
sphingomyelinase
Studies
Vitamin E
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Accumulating evidence suggests that aging is associated with dysregulated immune and inflammatory responses. Investigation into the cellular and molecular mechanisms underlying this phenomenon suggests that an up-regulated cyclooxygenase (COX)-2 expression, and resulting increase in production of prostaglandin E2 (PGE2), is a critical factor. Macrophages from old mice have significantly higher levels of PGE2 production compared with those from young mice, a result of increased COX-2 expression and protein levels leading to increased COX enzyme activity. Further, it is possible that the age-associated increase in macro-phage PGE2 production is due to ceramide-induced up-regulation of nuclear factor-kappa B activation. Such processes may also occur in cell types other than macrophages, lending further insight into potential mechanisms of age-related disease. More research is necessary to determine the efficacy of nutrient/dietary modifications, such as antioxidants and lipids, for reducing the age-related increase in COX activity and PGE2 production that are associated with several disease states.
ISSN:0029-6643
1753-4887
DOI:10.1111/j.1753-4887.2007.tb00365.x