Developmental expression of Mab21l2 during mouse embryogenesis

mab- 21 has been identified as a critical component required for sensory organ identity establishment in Caenorhabditis elegans. [Chow, K.L., Emmons, S.W., 1994. Development 120, 2579–2592; Chow, E.L., Hall, D.H., Emmons, S.W., 1995. Development 121, 3615-3625]. Human and mouse homologs of this gene...

Full description

Saved in:
Bibliographic Details
Published in:Mechanisms of development 1999-09, Vol.87 (1), p.185-188
Main Authors: Wong, Rebecca Lee Yean, Chan, Kenith Ka Lung, Chow, King Lau
Format: Article
Language:English
Subjects:
Animals
Bone and Bones - embryology
Ear - embryology
Embryo, Mammalian - metabolism
Expression pattern
Eye - embryology
Gene Expression
Homeodomain Proteins - genetics
Homeodomain Proteins - metabolism
In Situ Hybridization
Limb Buds - embryology
Mab21l2
Mice
Molecular Sequence Data
Mouse embryogenesis
Somites - metabolism
Time Factors
Umbilical Cord - embryology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:mab- 21 has been identified as a critical component required for sensory organ identity establishment in Caenorhabditis elegans. [Chow, K.L., Emmons, S.W., 1994. Development 120, 2579–2592; Chow, E.L., Hall, D.H., Emmons, S.W., 1995. Development 121, 3615-3625]. Human and mouse homologs of this gene have been isolated and their transcripts are predominantly detected in the eye and cerebellum [Margolis, R.L., Stine, O.C., McInnis, M.G., et al., 1996. Hum. Mol. Genet 5, 607–616; Mariani, M., Corradi, A., Baldessari, D., et al., 1998. Mech. Dev. 79, 131–135. We report here the expression profile of a second murine mab- 21 homolog, Mab21l2 [Wong, R.L.Y., Wong, H.T., Chow, K.L., 1999. Cyto. Cell Genet., [in press]. Whole mount in situ hybridization data from embryonic day 8.5 to day 15 revealed that Mab21l2 expression patterns partially overlapped with that of Mab21l1. In addition, its strong expression in the mid- and hindbrain, otic vesicle, optic vesicle, maxillary and mandibular process, paraxial mesoderm, dorsal midline, limb bud and developing digits suggest that Mab21l2 has more diverse functions in vertebrate development.
ISSN:0925-4773
1872-6356
DOI:10.1016/S0925-4773(99)00127-6