Cancer invasion and tissue remodeling: common themes in proteolytic matrix degradation

Analysis of extracellular matrix degradation systems has led to the insight that in cancer invasion there is often crucial interplay between cancer cells and several types of surrounding non-neoplastic stromal cells. Likewise, in normal tissue remodeling processes, the synthesis of proteolytic compo...

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Bibliographic Details
Published in:Current opinion in cell biology 1998-10, Vol.10 (5), p.667-671
Main Authors: Johnsen, Morten, Lund, Leif R, Rømer, John, Almholt, Kasper, Danø, Keld
Format: Article
Language:English
Subjects:
Breast Neoplasms - pathology
Colonic Neoplasms - pathology
Extracellular Matrix Proteins - metabolism
Neoplasm Invasiveness
Regeneration
Skin Neoplasms - pathology
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Summary:Analysis of extracellular matrix degradation systems has led to the insight that in cancer invasion there is often crucial interplay between cancer cells and several types of surrounding non-neoplastic stromal cells. Likewise, in normal tissue remodeling processes, the synthesis of proteolytic components is often distributed between several cell types, and there are strong similarities between neoplastic and non-neoplastic processes in the same tissue. Thus, tissue remodeling events are excellent models for studies of extracellular proteolysis in cancer. This has become even clearer by recent analyses of genetically modified mice.
ISSN:0955-0674
1879-0410
DOI:10.1016/S0955-0674(98)80044-6