Amygdala-kindled and electroconvulsive seizures alter hippocampal expression of the m1 and m3 muscarinic cholinergic receptor genes

Expression of m1 and m3 muscarinic cholinergic receptors mRNAs was examined in rat hippocampus following either: (1) kindling to five Stage 5 amygdala-kindled seizures; or (2) eight electroconvulsive shock (ECS) seizures. Twenty-four hours after the last seizure of either type, there was a significa...

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Bibliographic Details
Published in:Brain research 1998-11, Vol.810 (1), p.9-15
Main Authors: Mingo, Nancy S., Cottrell, Georgia A., Mendonça, Antonio, Gombos, Zoltan, Eubanks, James H., Burnham, W.McIntyre
Format: Article
Language:English
Subjects:
Amygdala - physiology
Animals
Biological and medical sciences
DNA Probes
Electroconvulsive shock seizure
Electrodes, Implanted
Electroshock
Gene Expression Regulation - physiology
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Hippocampus
Hippocampus - metabolism
Hippocampus - physiology
In Situ Hybridization
Kindled
Kindling, Neurologic - physiology
Male
Medical sciences
mRNA
Muscarinic cholinergic receptor
Nervous system (semeiology, syndromes)
Neurology
Rats
Receptors, Muscarinic - biosynthesis
Receptors, Muscarinic - genetics
Seizures - physiopathology
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Summary:Expression of m1 and m3 muscarinic cholinergic receptors mRNAs was examined in rat hippocampus following either: (1) kindling to five Stage 5 amygdala-kindled seizures; or (2) eight electroconvulsive shock (ECS) seizures. Twenty-four hours after the last seizure of either type, there was a significant decrease in both m1 and m3 mRNAs in CA1, CA3 and the dentate gyrus subfields of the hippocampus. Twenty-eight days after the last seizure of either type, there was a significant increase in m1 mRNAs in CA1, CA3, and the dentate gyrus; for m3 mRNAs, there was a significant increase in CA3 28 days after the last ECS seizure, and in CA1 and CA3 28 days after the last kindled seizure. These results suggest that seizures alter the cholinergic system in the hippocampus, and that some of the alterations are very long-lasting.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(98)00748-3