Low Rates of Antiretroviral Therapy among HIV-Infected Patients with Chronic Kidney Disease

Background. It is unknown whether chronic kidney disease (CKD) influences receipt of highly active antiretroviral therapy (HAART) among patients with the human immunodeficiency virus (HIV) and whether prescription practices contribute to excess mortality. Methods. We conducted a retrospective observ...

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Bibliographic Details
Published in:Clinical infectious diseases 2007-12, Vol.45 (12), p.1633-1639
Main Authors: Choi, Andy I., Rodriguez, Rudolph A., Bacchetti, Peter, Volberding, Paul A., Havlir, Diane, Bertenthal, Daniel, Bostrom, Alan, O'Hare, Ann M.
Format: Article
Language:English
Subjects:
Adult
AIDS
Anti-HIV Agents - administration & dosage
Anti-HIV Agents - pharmacokinetics
Anti-HIV Agents - therapeutic use
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiretroviral drugs
Antiretroviral Therapy, Highly Active
Antiretrovirals
Antiviral agents
Biological and medical sciences
Chronic Disease
Cohort Studies
Dialysis
Dosage
Drug therapy
Female
Highly active antiretroviral therapy
HIV
HIV Infections - complications
HIV Infections - drug therapy
HIV Infections - mortality
HIV/AIDS
Human immunodeficiency virus
Human viral diseases
Humans
Infectious diseases
Kidney diseases
Kidney Diseases - complications
Kidneys
Male
Medical sciences
Medications
Middle Aged
Mortality
Nephrology
Nephrology. Urinary tract diseases
Pharmacology. Drug treatments
Renal function
Retrospective Studies
Treatment Outcome
Urinary system involvement in other diseases. Miscellaneous
Veterans
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Summary:Background. It is unknown whether chronic kidney disease (CKD) influences receipt of highly active antiretroviral therapy (HAART) among patients with the human immunodeficiency virus (HIV) and whether prescription practices contribute to excess mortality. Methods. We conducted a retrospective observational study involving HIV-infected patients with established indications for HAART and an outpatient serum creatinine level measured in the Veterans Affairs health care system. Patients were followed up for the outcomes of HAART exposure (percentage of follow-up time treated with HAART), inadequate dose adjustment of renally eliminated antiretroviral medications, and time to death. Results. A total of 1041 patients (8.5%) had CKD, defined as an estimated glomerular filtration rate (eGFR)
ISSN:1058-4838
1537-6591
DOI:10.1086/523729