Identification of Mammaglobin B, a Novel Member of the Uteroglobin Gene Family

In this report, we have identified, sequenced, and characterized the expression pattern of a novel human gene, mammaglobin B. Mammaglobin B (MGB2) is highly homologous to mammaglobin (MGB1), a previously characterized human gene whose expression is limited to the mammary epithelium and frequently up...

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Bibliographic Details
Published in:Genomics (San Diego, Calif.) Calif.), 1998-11, Vol.54 (1), p.70-78
Main Authors: Becker, Robert M., Darrow, Christopher, Zimonjic, Drazen B., Popescu, Nicholas C., Watson, Mark A., Fleming, Timothy P.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Biological and medical sciences
Blotting, Northern
Breast - metabolism
Breast Neoplasms - metabolism
Chromosomes, Human, Pair 11 - genetics
Female
Fundamental and applied biological sciences. Psychology
Genes. Genome
Humans
In Situ Hybridization, Fluorescence
Mammaglobin A
Mammaglobin B
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
Myelin Proteins
Neoplasm Proteins - chemistry
Neoplasm Proteins - genetics
Neoplasm Proteins - metabolism
Polymerase Chain Reaction
Proteins - genetics
Proteolipids
RNA, Messenger - genetics
RNA, Messenger - metabolism
Salivary Glands - metabolism
Secretoglobins
Uterine Neoplasms - metabolism
Uteroglobin - chemistry
Uteroglobin - genetics
Uteroglobin - metabolism
Uterus - metabolism
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Summary:In this report, we have identified, sequenced, and characterized the expression pattern of a novel human gene, mammaglobin B. Mammaglobin B (MGB2) is highly homologous to mammaglobin (MGB1), a previously characterized human gene whose expression is limited to the mammary epithelium and frequently up-regulated in human breast cancer cells. Based upon amino acid sequence similarities, both mammaglobin and mammaglobin B may be considered members of a larger, mammalian multigene family that includes rabbit uteroglobin, human Clara Cell 10-kDa protein (CC10), and the multimeric rat prostatein protein. Together with the human CC10 gene, mammaglobin and mammaglobin B are closely linked on human chromosome 11q13. However, despite their primary sequence similarity and close chromosomal proximity, the expression of mammaglobin and mammaglobin B is nonconcordant in both nonmalignant and neoplastic tissue.
ISSN:0888-7543
1089-8646
DOI:10.1006/geno.1998.5539