Impaired splanchnic and peripheral glucose uptake in liver cirrhosis

Background/Aim: Patients with liver cirrhosis are insulin-resistant and frequently glucose-intolerant. Although peripheral glucose uptake has been shown to be impaired in liver cirrhosis, little is known about the significance of splanchnic (hepatic) glucose uptake after oral glucose load. Methods/R...

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Bibliographic Details
Published in:Journal of hepatology 1999-09, Vol.31 (3), p.469-473
Main Authors: Imano, Eiichi, Kanda, Tsutomu, Nakatani, Yoshihisa, Motomura, Masaaki, Arai, Katsumi, Matsuhisa, Munehide, Yamasaki, Yoshimitsu, Hori, Masatsugu
Format: Article
Language:English
Subjects:
Administration, Oral
Biological and medical sciences
Case-Control Studies
Digestive system
Glucose - metabolism
Glucose Intolerance
Glucose Tolerance Test
Hepatitis, Chronic - metabolism
Humans
Insulin Resistance
Investigative techniques, diagnostic techniques (general aspects)
Liver - metabolism
Liver cirrhosis
Liver Cirrhosis - metabolism
Medical sciences
Middle Aged
Muscles - metabolism
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Peripheral glucose uptake
Splanchnic Circulation - physiology
Splanchnic glucose uptake
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Summary:Background/Aim: Patients with liver cirrhosis are insulin-resistant and frequently glucose-intolerant. Although peripheral glucose uptake has been shown to be impaired in liver cirrhosis, little is known about the significance of splanchnic (hepatic) glucose uptake after oral glucose load. Methods/Results: We performed an oral glucose tolerance test and euglycemic hyperinsulinemic clamp with oral glucose load for eight patients with liver cirrhosis and eight patients with chronic active hepatitis. The patients with liver cirrhosis had higher plasma glucose levels 2 h after glucose load than those with chronic active hepatitis (228±22 mg/dl vs 102±9 mg/dl, p
ISSN:0168-8278
1600-0641
DOI:10.1016/S0168-8278(99)80039-7