Skin storage of cystine and premature skin ageing in cystinosis

Guillet conclude that it is impossible to know when skin deposition of cystine crystals starts, but the involvement of elastic fibers may give a clue about alterations on other elastic tissues of older patients and could be a useful index of treatment.

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Bibliographic Details
Published in:The Lancet (British edition) 1998-10, Vol.352 (9138), p.1444-1445
Main Authors: Guillet, G, Sassolas, B, Fromentoux, S, Gobin, E, Leroy, JP
Format: Article
Language:English
Subjects:
Adult
Aging
Biological and medical sciences
Cysteine - analysis
Cystinosis - pathology
Errors of metabolism
Fibroblasts - chemistry
Fibroblasts - ultrastructure
Humans
Immunosuppressive Agents - adverse effects
Kidney Transplantation - adverse effects
Male
Medical disorders
Medical sciences
Metabolic diseases
Proteins and glycoproteins
Skin
Skin - pathology
Skin Aging
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Description
Summary:Guillet conclude that it is impossible to know when skin deposition of cystine crystals starts, but the involvement of elastic fibers may give a clue about alterations on other elastic tissues of older patients and could be a useful index of treatment.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(05)61267-6