Structural and cytotoxic study of new Pt(II) and Pd(II) complexes with the bi-heterocyclic ligand mepirizole

Pd(II) and Pt(II) complexes of formulae [MLCl 2], where L=mepirizole, were synthesized and characterized. Two complexes were obtained and studied by different techniques: IR, 1H and 13C NMR and XPS spectroscopies and mass spectrometry (electrospray). The crystal structure of the complex cis-dichloro...

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Bibliographic Details
Published in:Journal of inorganic biochemistry 1999-06, Vol.75 (3), p.205-212
Main Authors: Onoa, G.B, Moreno, V, Font-Bardia, M, Solans, X, Pérez, J.M, Alonso, C
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Cell Division - drug effects
Cell Line, Transformed
Cercopithecus aethiops
Crystallography, X-Ray
Cytotoxic activity
Epirizole - chemistry
Epirizole - pharmacology
HL-60 Cells
Humans
Jurkat Cells
Ligands
Mepirizole
Mice
Palladium - chemistry
Pd(II)-bi-heterocyclic complex
Pd–mepirizole crystal structure
Platinum - chemistry
Pt(II)-bi-heterocyclic complex
Spectrum Analysis
Structure-Activity Relationship
Vero Cells
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Summary:Pd(II) and Pt(II) complexes of formulae [MLCl 2], where L=mepirizole, were synthesized and characterized. Two complexes were obtained and studied by different techniques: IR, 1H and 13C NMR and XPS spectroscopies and mass spectrometry (electrospray). The crystal structure of the complex cis-dichloro-4-methoxy-2-(5-methoxy-3-methyl-pyrazol-1-yl)-6-methyl-pyrimidinepalladium(II), [Pd(mep)Cl 2], was studied by crystal X-ray diffraction. It consists of discrete molecules with planar geometry. Pd(II) ions are four-coordinated by two mepirizole nitrogen atoms (N1 from the pyrazole ring and N4 from the pyrimidine ring) and two chlorine atoms. The geometry of the PdN 2Cl 2 chromophore is a distortion of the square-planar coordination. Data from powder pattern X-ray diffraction of cis-dichloro-4-methoxy-2-(5-methoxy-3-methyl-pyrazol-1-yl)-6-methyl-pyrimidineplatinum(II), [Pt(mep)Cl 2], demonstrated that the two complexes are isostructural. The cytotoxic activity of both Pd and Pt complexes was checked for six different tumor cell lines and was lower than that of cisplatin. The Pt bound to DNA was also checked and only a low percentage is able to cross the cell membrane.
ISSN:0162-0134
1873-3344
DOI:10.1016/S0162-0134(99)00089-6