The outcome of intracytoplasmic sperm injection in patients with retrograde ejaculation

The objective of this retrospective clinical study was to assess the benefit of assisted fertilization in cases of anejaculatory infertility due to retrograde ejaculation. We report the outcome of intracytoplasmic sperm injection (ICSI) treatment. In 16 couples in which the men suffered from retrogr...

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Bibliographic Details
Published in:Human reproduction (Oxford) 1999-09, Vol.14 (9), p.2293-2296
Main Authors: Nikolettos, N., Al-Hasani, S., Baukloh, V., Schöpper, B., Demirel, L.C., Baban, N., Sturm, R., Rudolf, K., Tomalak, K., Tinneberg, H.R., Diedrich, K.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Ejaculation
Embryo Transfer
Female
Fertilization in Vitro - methods
Gynecology. Andrology. Obstetrics
Humans
Hydrogen-Ion Concentration
ICSI
infertility
Infertility, Male - therapy
Male
Male genital diseases
Medical sciences
Microinjections
Middle Aged
Non tumoral diseases
Oocytes - ultrastructure
Pregnancy
retrograde ejaculation
Retrospective Studies
Treatment Outcome
Urine
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Summary:The objective of this retrospective clinical study was to assess the benefit of assisted fertilization in cases of anejaculatory infertility due to retrograde ejaculation. We report the outcome of intracytoplasmic sperm injection (ICSI) treatment. In 16 couples in which the men suffered from retrograde ejaculation. We performed 35 cycles of ICSI with spermatozoa retrieved from post-ejaculatory urine. The patients had been instructed to alkalinize the urine by ingesting sodium bicarbonate before the procedure. The fertilization rate averaged 51.2%. Seven clinical pregnancies were achieved. Three spontaneous first trimester abortions occurred, but three live offspring were delivered and one pregnancy is ongoing. In conclusion, the use of ICSI may be feasible for patients with retrograde ejaculation who are resistant to medical treatment and whose sperm quality is so low or unpredictable that intrauterine insemination or conventional methods of in-vitro fertilization are not possible.
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/14.9.2293