Pediatric liver neoplasms: a radiologic-pathologic correlation

Only 1-2 % of all pediatric tumors occur in the liver. Two thirds of these tumors are malignant and almost all of the tumors cause clinical symptoms due to their mass effects. Besides the poor prognosis in most of the malignant tumors, for further treatment the origin and nature of the neoplasm has...

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Bibliographic Details
Published in:European radiology 1999, Vol.9 (7), p.1339-1347
Main Authors: Helmberger, T K, Ros, P R, Mergo, P J, Tomczak, R, Reiser, M F
Format: Article
Language:English
Subjects:
Carcinoma, Hepatocellular - diagnosis
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - surgery
Child
Diagnostic Imaging
Hamartoma - diagnosis
Hamartoma - pathology
Hamartoma - surgery
Hemangioendothelioma - diagnosis
Hemangioendothelioma - pathology
Hemangioendothelioma - surgery
Hepatoblastoma - diagnosis
Hepatoblastoma - pathology
Hepatoblastoma - surgery
Humans
Liver - pathology
Liver Diseases - diagnosis
Liver Diseases - pathology
Liver Diseases - surgery
Liver Neoplasms - diagnosis
Liver Neoplasms - pathology
Liver Neoplasms - surgery
Medical imaging
Neoplasms, Germ Cell and Embryonal - diagnosis
Neoplasms, Germ Cell and Embryonal - pathology
Neoplasms, Germ Cell and Embryonal - surgery
Pediatrics
Prognosis
Tumors
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Description
Summary:Only 1-2 % of all pediatric tumors occur in the liver. Two thirds of these tumors are malignant and almost all of the tumors cause clinical symptoms due to their mass effects. Besides the poor prognosis in most of the malignant tumors, for further treatment the origin and nature of the neoplasm has to be known. Due to the mostly unimpeded growth into the peritoneal cavity, the origin of the tumors is primarily often unclear and can non-invasively only be determined by advanced imaging techniques. The display of the macro- and microhistological key features of primary pediatric liver neoplasms, including hepatoblastoma (HB), infantile hemangioendothelioma (IHE), mesenchymal hamartoma (MH), undifferentiated (embryonal) sarcoma (UES), and hepatocellular carcinoma (HCC), together with their imaging representation by ultrasound, computed tomography, and magnetic resonance imaging, may deepen the understanding of the underlying pathology and its imaging appearance. Furthermore, in many cases sufficient information may be provided not only to differentiate benign from malignant tumors, but also to guide for adequate treatment.
ISSN:0938-7994
1432-1084
DOI:10.1007/s003300050845