Isolated isochromosome 17q: a distinct type of mixed myeloproliferative disorder/myelodysplastic syndrome with an aggressive clinical course

A clinicopathologic study was performed on 15 patients with haematological malignancies in which isochromosome 17q [i(17q)] was the sole structural chromosome abnormality identified in bone marrow. The data indicated that an isolated i(17q) is associated with a distinct type of mixed chronic myelopr...

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Bibliographic Details
Published in:British journal of haematology 1999-08, Vol.106 (2), p.445-454
Main Authors: McClure, R. F., Dewald, G. W., Hoyer, J. D., Hanson, C. A.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Chromosomes, Human, Pair 17 - genetics
chronic myeloproliferative disorder
Disease-Free Survival
Female
Hematologic and hematopoietic diseases
Hematology
Humans
In Situ Hybridization, Fluorescence
isochromosome 17q
Isochromosomes - genetics
Karyotyping
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Middle Aged
myelodysplastic syndrome
Myelodysplastic Syndromes - genetics
Myeloproliferative Disorders - genetics
pseudo‐Pelger‐Huet neutrophils
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Summary:A clinicopathologic study was performed on 15 patients with haematological malignancies in which isochromosome 17q [i(17q)] was the sole structural chromosome abnormality identified in bone marrow. The data indicated that an isolated i(17q) is associated with a distinct type of mixed chronic myeloproliferative/myelodysplastic disorder with an aggressive clinical course. The patients ranged in age from 37 to 83 years (median 60) with a M:F ratio of 3:1. All cases were chronic myeloid disorders with mixed proliferative and dysplastic features, making classification difficult. 11 patients tested for BCR/ABL gene fusion were normal. A low bone marrow blast count (
ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.1999.01537.x