Parathyroid Hormone‐Related Protein mRNA and Protein Expression in Multiple Myeloma: A Case Report

Multiple myeloma frequently leads to complications, such as osteolytic lesions, hypercalcemia, and pathological fractures. Increased bone resorption in myeloma is due to osteoclast activation. The nature of the osteoclast activator(s) remains unclear. We describe a case of multiple myeloma with mark...

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Bibliographic Details
Published in:Journal of bone and mineral research 1998-10, Vol.13 (10), p.1640-1643
Main Authors: Schneider, Hans‐Gerhard, Kartsogiannis, Vicky, Zhou, Hong, Chou, S. T., Martin, T. John, Grill, Vivian
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Biopsy
Bone Marrow - pathology
Gene Expression Regulation, Neoplastic
Humans
Hypercalcemia - complications
Hypercalcemia - genetics
Immunodeficiencies. Immunoglobulinopathies
Immunoglobulinopathies
Immunopathology
Male
Medical sciences
Multiple Myeloma - blood
Multiple Myeloma - genetics
Multiple Myeloma - metabolism
Neoplasm Proteins - genetics
Parathyroid Hormone - genetics
Parathyroid Hormone-Related Protein
Protein Biosynthesis
Proteins - genetics
RNA, Messenger - analysis
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Summary:Multiple myeloma frequently leads to complications, such as osteolytic lesions, hypercalcemia, and pathological fractures. Increased bone resorption in myeloma is due to osteoclast activation. The nature of the osteoclast activator(s) remains unclear. We describe a case of multiple myeloma with marked hypercalcemia and skeletal complications that progressed rapidly despite chemotherapy. The patient had marked hypercalcemia at diagnosis (4.5 mmol/l), and elevated parathyroid hormone‐related protein (PTHrP) levels were found in plasma. Analysis of the bone marrow trephine biopsy showed PTHrP gene transcription and protein in myeloma cells. These results provide strong evidence for the production of significant amounts of PTHrP by human myeloma cells. PTHrP has been measured as elevated in the plasma of patients with myeloma and might be an important contributor to the skeletal complications in this disease.
ISSN:0884-0431
1523-4681
DOI:10.1359/jbmr.1998.13.10.1640