Supraspinal hyperalgesia and spinal analgesia by [Phe1ψ(CH2-NH)Gly2]nociceptin-(1-13)-NH2 in rat

[Phe1psi(CH2-NH)Gly2]nociceptin-(1-13)-NH2, a pseudopeptide analog of nociceptin, was originally seen as an antagonist of nociceptin receptors. In the present study, it was observed that intracerebroventricular (i.c.v.) injection of this pseudopeptide (1, 5, 10 microg) significantly decreased the ta...

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Bibliographic Details
Published in:European journal of pharmacology 1999-07, Vol.376 (3), p.R1-R3
Main Authors: WANG, Y.-Q, ZHU, C.-B, CAO, X.-D, WU, G.-C
Format: Article
Language:English
Subjects:
Analgesia
Animals
Biological and medical sciences
Cell receptors
Cell structures and functions
Fundamental and applied biological sciences. Psychology
Hyperalgesia - drug therapy
Male
Miscellaneous
Molecular and cellular biology
Nociceptin
Opioid Peptides - administration & dosage
Pain Measurement - drug effects
Rats
Rats, Sprague-Dawley
Receptors, Opioid - administration & dosage
Receptors, Opioid - agonists
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Summary:[Phe1psi(CH2-NH)Gly2]nociceptin-(1-13)-NH2, a pseudopeptide analog of nociceptin, was originally seen as an antagonist of nociceptin receptors. In the present study, it was observed that intracerebroventricular (i.c.v.) injection of this pseudopeptide (1, 5, 10 microg) significantly decreased the tail-flick latency of rats, indicating a hyperalgesic effect, while intrathecal (i.t.) injection of it (1, 2.5, 10 microg) dramatically increased the tail-flick latency, indicating an analgesic effect. This strengthened the in vivo evidence that [Phe1psi(CH2NH)Gly2]nociceptin-(1-13)-NH2 might be an agonist of nociceptin receptors.
ISSN:0014-2999
1879-0712
DOI:10.1016/S0014-2999(99)00399-4