A mosquito ( Anopheles stephensi) angiotensin I-converting enzyme (ACE) is induced by a blood meal and accumulates in the developing ovary

Angiotensin I-converting enzyme (ACE) has a key role in regulating levels of several circulating peptides in mammals and has a vital role in male fertility. ACE has recently been found in insects, where its role is unclear. A mutant allele of the ACE gene (Ance) of Drosophila melanogaster is embryon...

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Bibliographic Details
Published in:FEBS letters 1999-07, Vol.455 (3), p.219-222
Main Authors: Ekbote, U, Coates, D, Isaac, R.E
Format: Article
Language:English
Subjects:
Angiotensin I-converting enzyme
Angiotensin-Converting Enzyme Inhibitors - pharmacology
Animals
Anopheles - enzymology
Anopheles - growth & development
Anopheles - physiology
Anopheles stephensi
Blood
Captopril - pharmacology
Eating
Female
Lisinopril - pharmacology
Male
Molecular Weight
Mosquito
Ovary - enzymology
Ovary - growth & development
Peptide metabolism
Peptidyl-Dipeptidase A - biosynthesis
Peptidyl-Dipeptidase A - chemistry
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Summary:Angiotensin I-converting enzyme (ACE) has a key role in regulating levels of several circulating peptides in mammals and has a vital role in male fertility. ACE has recently been found in insects, where its role is unclear. A mutant allele of the ACE gene (Ance) of Drosophila melanogaster is embryonic lethal, indicating an important role for the enzyme in development. We now report the presence of ACE in female Anopheles stephensi mosquitoes and that the enzyme is induced by a blood-meal. ACE accumulates in developing ovaries and passes into the mosquito eggs, where it may play a role in the metabolism of peptides during embryogenesis. The ovarian ACE has an M r of 70 kDa and is inhibited by captopril and lisinopril with IC 50 values of 0.1 μM and 0.6 μM, respectively.
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(99)00870-4