Recovery after anaesthesia for pulmonary surgery: desflurane, sevoflurane and isoflurane

We have studied maintenance and recovery profiles after general anaesthesia with sevoflurane, desflurane and isoflurane in 100 patients undergoing pulmonary surgery. End-tidal concentrations of anaesthetic required to maintain mean arterial pressure and heart rate within 20% of baseline values were...

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Bibliographic Details
Published in:British Journal of Anaesthesia 1999-03, Vol.82 (3), p.355-359
Main Authors: Dupont, J, Tavernier, B, Ghosez, Y, Durinck, L, Thevenot, A, Moktadir-Chalons, N, Ruyffelaere-Moises, L, Declerck, N, Scherpereel, P
Format: Article
Language:English
Subjects:
Adult
Aged
Anesthesia Recovery Period
Anesthetics, Inhalation - pharmacology
Anesthetics. Neuromuscular blocking agents
Biological and medical sciences
Blood Pressure - drug effects
Cognition - drug effects
Desflurane
Female
Heart Rate - drug effects
Humans
Isoflurane - analogs & derivatives
Isoflurane - pharmacology
Lung - surgery
Male
Medical sciences
Methyl Ethers - pharmacology
Middle Aged
Neuropharmacology
Oxygen - blood
Pharmacology. Drug treatments
Prospective Studies
Sevoflurane
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Summary:We have studied maintenance and recovery profiles after general anaesthesia with sevoflurane, desflurane and isoflurane in 100 patients undergoing pulmonary surgery. End-tidal concentrations of anaesthetic required to maintain mean arterial pressure and heart rate within 20% of baseline values were 1.4 +/- 0.6% for sevoflurane, 3.4 +/- 0.9% for desflurane and 0.7 +/- 0.3% for isoflurane. The three anaesthetics had comparable haemodynamic effects and arterial oxygenation during one-lung ventilation. Emergence was twice as fast with desflurane than with sevoflurane or isoflurane (mean times to extubation: 8.9 (SD 5.0) min, 18.0 (17.0) min and 16.2 (11.0) min for desflurane, sevoflurane and isoflurane, respectively). Early recovery (Aldrete score, cognitive and psychomotor functions) was also more rapid after desflurane. In pulmonary surgery, desflurane, but not sevoflurane, allowed more rapid emergence and earlier recovery than isoflurane.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/82.3.355