Reliability, Validity, and Application of the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) in Schizophrenic Patients Treated with Olanzapine versus Haloperidol

Schizophrenia leads to impairments in mental, social, and physical functioning, which should be included in evaluations of treatment. Objectives. This study was designed to determine the reliability and validity of the Medical Outcomes Study Short Form Health Survey (SF-36) for schizophrenic patient...

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Bibliographic Details
Published in:Medical care 1999-07, Vol.37 (7), p.678-691
Main Authors: Tunis, Sandra L., Croghan, Thomas W., Heilman, Douglas K., Johnstone, Bryan M., Obenchain, Robert L.
Format: Article
Language:English
Subjects:
Activities of Daily Living
Adult
Antipsychotic Agents - economics
Antipsychotic Agents - therapeutic use
Benzodiazepines
Clinical trials
Cost of Illness
Cost-Benefit Analysis
Discriminant Analysis
Diseases
Emotional problems
Factor Analysis, Statistical
Female
Haloperidol - economics
Haloperidol - therapeutic use
Health Status Indicators
Humans
Male
Mental health
Middle Aged
Olanzapine
Physical health
Pirenzepine - analogs & derivatives
Pirenzepine - economics
Pirenzepine - therapeutic use
Population mean
Psychometrics
Reproducibility of Results
Schizophrenia
Schizophrenia - drug therapy
Surveys and Questionnaires - standards
Treatment Outcome
Vitality
Wellbeing
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Summary:Schizophrenia leads to impairments in mental, social, and physical functioning, which should be included in evaluations of treatment. Objectives. This study was designed to determine the reliability and validity of the Medical Outcomes Study Short Form Health Survey (SF-36) for schizophrenic patients, to characterize perceived functioning and well being and to compare short-term change in SF-36 scores for patients treated with olanzapine or haloperidol. Research Design. Data were obtained from a randomized, double-blind trial comparing these agents for safety, efficacy, and cost effectiveness. A 6-week acute treatment portion preceded a 46-week "responder extension" phase. Subjects. A subsample (n = 1,155) completing a pre-treatment SF-36 provided data for this study. Measures. Psychometric analyses were conducted, and perceived level of functioning was compared with that for the US adult population. Change from baseline to 6 weeks was examined by treatment group. Results. Clear evidence was obtained for the instrument's reliability and validity for these patients. There were marked deficits in General health, Vitality, Mental health, Social functioning, and in Role limitations resulting from both physical and emotional problems. Olanzapine-treated patients improved in 5 of 8 domains to a significantly greater degree than did haloperidol patients. Conclusions. The SF-36 can be a reliable and valid measure of perceived functioning and well being for schizophrenic patients. The perceptions of functioning can be valuable indices of disease burden and can help to demonstrate the effectiveness of newer antipsychotic medications such as olanzapine.
ISSN:0025-7079
1537-1948
DOI:10.1097/00005650-199907000-00008