Effects of Hyperinsulinemia on vascular blood flows in experimental obesity

Human obesity, which is very common in Polycystic Ovaries Syndrome and in “ X Syndrome”, constitutes an insulin-resistance state in which multiple clinical, biochemical and hemodynamic alterations coexist. Insulin resistance in the obese has been recently associated with an endothelial dysfunction....

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Bibliographic Details
Published in:Journal of steroid biochemistry and molecular biology 1999-04, Vol.69 (1), p.273-279
Main Authors: Villa, Eduardo, González-Albarrán, Olga, Rábano, Alberto, Garcı́a-Robles, Rafael
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood Circulation
Dogs
Femur - blood supply
Hyperinsulinism - physiopathology
Insulin Resistance
Kidney - blood supply
Male
Medical sciences
Mesentery - blood supply
Metabolic diseases
Obesity
Obesity - physiopathology
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Summary:Human obesity, which is very common in Polycystic Ovaries Syndrome and in “ X Syndrome”, constitutes an insulin-resistance state in which multiple clinical, biochemical and hemodynamic alterations coexist. Insulin resistance in the obese has been recently associated with an endothelial dysfunction. To investigate the possibility that clinical and metabolic derangements related to insulin resistance could induce changes in vascular blood flows, we have studied the levels of mesenteric (MBF), renal (RBF) and femoral (FBF) blood flows in Beagle dogs kept for 2 years on a normal (control group) or high fat diet (obese group). This experimental model exhibits many of the abnormalities with the human syndrome. In addition, we have tested the effects of chronic treatment with captopril (capto group) in monotherapy or in association with pravastatin (prava+capto group) on the hemodynamic changes associated with this diet. After the two year follow-up, Transonic flow probes were placed around the three arteries to measure basal blood flows and their response to a hyperinsulinemic-normoglycemic test in anesthetized animals. During this test the degree of insulin sensitivity was estimated. In association with higher body weight, blood pressure, insulin resistance, and fasting levels of insulin and total cholesterol, the obese group exhibited decreased basal levels of FBF and a greater femoral vasoconstriction during hyperinsulinism ( P
ISSN:0960-0760
1879-1220
DOI:10.1016/S0960-0760(99)00045-X