Evaluating sub-clinical cognitive dysfunction and event-related potentials (P300) in clinically isolated syndrome

Objective This study investigated the presence of sub-clinical cognitive dysfunction in patients with clinically isolated syndrome (CIS) and the abnormalities of cognitive event-related potentials (ERPs). Methods Subclinical cognitive dysfunction was assessed in 20 patients with CIS and in 20 health...

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Bibliographic Details
Published in:Neurological sciences 2008-12, Vol.29 (6), p.435-444
Main Authors: Kocer, Belgin, Unal, Tugba, Nazliel, Bijen, Biyikli, Zeynep, Yesilbudak, Zulal, Karakas, Sirel, Irkec, Ceyla
Format: Article
Language:English
Subjects:
Adult
Cerebral Cortex - physiopathology
Cognition Disorders - diagnosis
Cognition Disorders - etiology
Cognition Disorders - physiopathology
Disability Evaluation
Disease Progression
Electroencephalography - methods
Evoked Potentials - physiology
Female
Humans
Learning Disorders - diagnosis
Learning Disorders - physiopathology
Male
Medicine
Medicine & Public Health
Memory Disorders - diagnosis
Memory Disorders - physiopathology
Multiple Sclerosis - complications
Multiple Sclerosis - diagnosis
Multiple Sclerosis - physiopathology
Neurology
Neuropsychological Tests
Neuroradiology
Neurosciences
Neurosurgery
Original Article
Predictive Value of Tests
Psychiatry
Reaction Time - physiology
Young Adult
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Summary:Objective This study investigated the presence of sub-clinical cognitive dysfunction in patients with clinically isolated syndrome (CIS) and the abnormalities of cognitive event-related potentials (ERPs). Methods Subclinical cognitive dysfunction was assessed in 20 patients with CIS and in 20 healthy controls. Results Patients had impairments in verbal learning and long-term memory, evaluating attention, executive function and visuospatial skills, in decreasing order of frequency. SDLT and SIT were the most, and COWAT and BNT were the least affected tests. The N200 and P200 latencies were prolonged, and N100, N200 and P200 amplitudes were reduced in the patients relative to the controls, from the Fz, Cz and Pz electrode positions ( p
ISSN:1590-1874
1590-3478
DOI:10.1007/s10072-008-1020-4