Hepatitis E virus as a newly identified cause of acute viral hepatitis during human immunodeficiency virus infection

The recent description of chronic hepatitis E in organ transplant recipients deserves increased awareness in the context of hepatitis E virus (HEV) infection in immunocompromised individuals. Reported here is what is apparently the first PCR-documented case of acute hepatitis E in a human immunodefi...

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Bibliographic Details
Published in:Clinical microbiology and infection 2008-12, Vol.14 (12), p.1176-1180
Main Authors: Colson, P., Dhiver, C., Gérolami, R.
Format: Article
Language:English
Subjects:
Acute hepatitis
autochthonous hepatitis E
Biological and medical sciences
CD4 Lymphocyte Count
Genotype
Hepatitis Antibodies - blood
Hepatitis E - diagnosis
Hepatitis E virus
Hepatitis E virus - classification
Hepatitis E virus - genetics
Hepatitis E virus - isolation & purification
hepatitis E virus
HIV infection
HIV Infections - complications
Human immunodeficiency virus
Human viral diseases
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunoglobulin M - blood
Immunopathology
immunosuppression
Infectious diseases
Male
Medical sciences
Middle Aged
RNA, Viral - blood
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral hepatitis
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Summary:The recent description of chronic hepatitis E in organ transplant recipients deserves increased awareness in the context of hepatitis E virus (HEV) infection in immunocompromised individuals. Reported here is what is apparently the first PCR-documented case of acute hepatitis E in a human immunodeficiency virus (HIV)-l-infected patient. The CD4+ T-lymphocyte count was 246/mm3. The IgM anti-HEV antibody and HEV RNA tests results from serum were positive. Hepatitis was benign, and chronic HEV infection was ruled out. The HEV genotype was 3f. The patient did not report recent travel abroad. HEV should be tested in HIV-infected individuals presenting with acute hepatitis. HEV RNA detection is useful in diagnosing HEV infection and in monitoring recovery.
ISSN:1198-743X
1469-0691
DOI:10.1111/j.1469-0691.2008.02102.x